Identification of fluocinolone acetonide to prevent paclitaxel-induced peripheral neuropathy

Aysel Cetinkaya-Fisgin, Min Geol Joo, Xiang Ping, Nitish V. Thakor, Cengizhan Ozturk, Ahmet Hoke, In Hong Yang

Research output: Contribution to journalArticle

Abstract

Paclitaxel (PTX) is among the most commonly used cancer drugs that cause chemotherapy-induced peripheral neuropathy (CIPN), a debilitating and serious dose-limiting side effect. Currently, no drugs exist to prevent CIPN, and symptomatic therapy is often ineffective. In order to identify therapeutic candidates to prevent axonal degeneration induced by PTX, we carried out a phenotypic drug screening using primary rodent dorsal root ganglion sensory neurons. We identified fluocinolone acetonide as a neuroprotective compound and verified it through secondary screens. Furthermore, we showed its efficacy in a mouse model of PTX-induced peripheral neuropathy and confirmed with four different cancer cell lines that fluocinolone acetonide does not interfere with PTX's antitumor activity. Our study identifies fluocinolone acetonide as a potential therapy to prevent CIPN caused by PTX.

Original languageEnglish (US)
Pages (from-to)128-133
Number of pages6
JournalJournal of the Peripheral Nervous System
Volume21
Issue number3
DOIs
StatePublished - Jan 1 2016

Keywords

  • chemotherapy-induced peripheral neuropathy
  • fluocinolone acetonide
  • paclitaxel
  • phenotypic drug screening

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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