Identification of endothelin-1 in the pathophysiology of metastatic adenocarcinoma of the prostate

Joel B. Nelson; Sean P. Hedican; Daniel J. George; A. H. Reddi; Steven Piantadosi; Mario A. Eisenberger; Jonathan W. Simons

doi:10.1038/nm0995-944

Identification of endothelin-1 in the pathophysiology of metastatic adenocarcinoma of the prostate

Joel B. Nelson, Sean P. Hedican, Daniel J. George, A. H. Reddi, Steven Piantadosi, Mario A. Eisenberger, Jonathan W. Simons

Research output: Contribution to journal › Article › peer-review

545 Scopus citations

Abstract

Prostate cancer is the second most common cause of death from cancer in U.S. men, and advanced, hormone-refractory disease is characterized by painful osteoblastic bone metastases. Endothelin-1, more commonly known as a potent vasoconstrictor, is a normal ejaculate protein that also stimulates osteoblasts. We show here that plasma immunoreactive endothelin concentrations are significantly elevated in men with metastatic prostate cancer and that every human prostate cancer cell line tested produces endothelin-1 messenger RNA and secretes immunoreactive endothelin. Exogenous endothelin-1 is a prostate cancer mitogen in vitro and increases alkaline phosphatase activity in new bone formation, indicating that ectopic endothelin-1 may be a mediator of the osteoblastic response of bone to metastatic prostate cancer.

Original language	English (US)
Pages (from-to)	944-949
Number of pages	6
Journal	Nature medicine
Volume	1
Issue number	9
DOIs	https://doi.org/10.1038/nm0995-944
State	Published - Sep 1995
Externally published	Yes

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

Access to Document

10.1038/nm0995-944

Cite this

@article{efc7f4ddb0ed4b38b60310b8bb0f78e1,

title = "Identification of endothelin-1 in the pathophysiology of metastatic adenocarcinoma of the prostate",

abstract = "Prostate cancer is the second most common cause of death from cancer in U.S. men, and advanced, hormone-refractory disease is characterized by painful osteoblastic bone metastases. Endothelin-1, more commonly known as a potent vasoconstrictor, is a normal ejaculate protein that also stimulates osteoblasts. We show here that plasma immunoreactive endothelin concentrations are significantly elevated in men with metastatic prostate cancer and that every human prostate cancer cell line tested produces endothelin-1 messenger RNA and secretes immunoreactive endothelin. Exogenous endothelin-1 is a prostate cancer mitogen in vitro and increases alkaline phosphatase activity in new bone formation, indicating that ectopic endothelin-1 may be a mediator of the osteoblastic response of bone to metastatic prostate cancer.",

author = "Nelson, {Joel B.} and Hedican, {Sean P.} and George, {Daniel J.} and Reddi, {A. H.} and Steven Piantadosi and Eisenberger, {Mario A.} and Simons, {Jonathan W.}",

year = "1995",

month = sep,

doi = "10.1038/nm0995-944",

language = "English (US)",

volume = "1",

pages = "944--949",

journal = "Nature medicine",

issn = "1078-8956",

publisher = "Nature Publishing Group",

number = "9",

}

TY - JOUR

T1 - Identification of endothelin-1 in the pathophysiology of metastatic adenocarcinoma of the prostate

AU - Nelson, Joel B.

AU - Hedican, Sean P.

AU - George, Daniel J.

AU - Reddi, A. H.

AU - Piantadosi, Steven

AU - Eisenberger, Mario A.

AU - Simons, Jonathan W.

PY - 1995/9

Y1 - 1995/9

N2 - Prostate cancer is the second most common cause of death from cancer in U.S. men, and advanced, hormone-refractory disease is characterized by painful osteoblastic bone metastases. Endothelin-1, more commonly known as a potent vasoconstrictor, is a normal ejaculate protein that also stimulates osteoblasts. We show here that plasma immunoreactive endothelin concentrations are significantly elevated in men with metastatic prostate cancer and that every human prostate cancer cell line tested produces endothelin-1 messenger RNA and secretes immunoreactive endothelin. Exogenous endothelin-1 is a prostate cancer mitogen in vitro and increases alkaline phosphatase activity in new bone formation, indicating that ectopic endothelin-1 may be a mediator of the osteoblastic response of bone to metastatic prostate cancer.

AB - Prostate cancer is the second most common cause of death from cancer in U.S. men, and advanced, hormone-refractory disease is characterized by painful osteoblastic bone metastases. Endothelin-1, more commonly known as a potent vasoconstrictor, is a normal ejaculate protein that also stimulates osteoblasts. We show here that plasma immunoreactive endothelin concentrations are significantly elevated in men with metastatic prostate cancer and that every human prostate cancer cell line tested produces endothelin-1 messenger RNA and secretes immunoreactive endothelin. Exogenous endothelin-1 is a prostate cancer mitogen in vitro and increases alkaline phosphatase activity in new bone formation, indicating that ectopic endothelin-1 may be a mediator of the osteoblastic response of bone to metastatic prostate cancer.

UR - http://www.scopus.com/inward/record.url?scp=0029085123&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029085123&partnerID=8YFLogxK

U2 - 10.1038/nm0995-944

DO - 10.1038/nm0995-944

M3 - Article

C2 - 7585222

AN - SCOPUS:0029085123

SN - 1078-8956

VL - 1

SP - 944

EP - 949

JO - Nature medicine

JF - Nature medicine

IS - 9

ER -

Identification of endothelin-1 in the pathophysiology of metastatic adenocarcinoma of the prostate

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this