Identification of der(1;19)(q10;p10) in five oligodendrogliomas suggests mechanism of concurrent 1p and 19q loss

Constance A. Griffin, Peter Burger, Laura Morsberger, Raluca Yonescu, Sharon Swierczynski, Jon David Weingart, Kathleen M. Murphy

Research output: Contribution to journalArticle

Abstract

Deletions of portions of chromosomes 1p and 19q are closely associated with the oligodendroglioma histologic phenotype. In most cases, 1p and 19q are codeleted, yet the mechanism of dual loss is unexplained. We report 5 cases (World Health Organization grade III) in which metaphase cytogenetics identified a derivative chromosome consisting of what appears to be the whole arms of 1q and 19p forming a der(1;19)(q10;p10). Metaphase fluorescent in situ hybridization (FISH) confirmed the derivative chromosome was composed of 1q and 19p material in 3 cases; in 2 cases with few metaphases, FISH confirmed 19p material on the derivative chromosome. In all cases, interphase FISH showed net loss of 1p and 19q in 77% to 92% of cells, and microsatellite studies were consistent with 1p and 19q loss. We hypothesize the following: occurrence of a balanced whole-arm translocation between chromosomes 1 and 19 forming 2 derivative chromosomes, one composed of 1q and 19p, the other of 1p and 19q. Subsequent loss of the der(1;19)(p10;q10) then results in the simultaneous 1p and 19q loss observed in oligodendroglioma with retention of the der(1;19)(q10;p10) seen in these cases.

Original languageEnglish (US)
Pages (from-to)988-994
Number of pages7
JournalJournal of Neuropathology and Experimental Neurology
Volume65
Issue number10
DOIs
StatePublished - Oct 2006

Fingerprint

Oligodendroglioma
Metaphase
Fluorescence In Situ Hybridization
Chromosomes
Chromosomes, Human, Pair 19
Chromosome Deletion
Chromosomes, Human, Pair 2
Chromosomes, Human, Pair 1
Interphase
Cytogenetics
Microsatellite Repeats
Phenotype

Keywords

  • Brain tumor
  • Chromosome
  • Fluorescent in situ hybridization (FISH)
  • Karyotype
  • Oligodendroglioma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Neuroscience(all)

Cite this

Identification of der(1;19)(q10;p10) in five oligodendrogliomas suggests mechanism of concurrent 1p and 19q loss. / Griffin, Constance A.; Burger, Peter; Morsberger, Laura; Yonescu, Raluca; Swierczynski, Sharon; Weingart, Jon David; Murphy, Kathleen M.

In: Journal of Neuropathology and Experimental Neurology, Vol. 65, No. 10, 10.2006, p. 988-994.

Research output: Contribution to journalArticle

Griffin, Constance A. ; Burger, Peter ; Morsberger, Laura ; Yonescu, Raluca ; Swierczynski, Sharon ; Weingart, Jon David ; Murphy, Kathleen M. / Identification of der(1;19)(q10;p10) in five oligodendrogliomas suggests mechanism of concurrent 1p and 19q loss. In: Journal of Neuropathology and Experimental Neurology. 2006 ; Vol. 65, No. 10. pp. 988-994.
@article{7efc5afc824e4d6496424fcf803ebda0,
title = "Identification of der(1;19)(q10;p10) in five oligodendrogliomas suggests mechanism of concurrent 1p and 19q loss",
abstract = "Deletions of portions of chromosomes 1p and 19q are closely associated with the oligodendroglioma histologic phenotype. In most cases, 1p and 19q are codeleted, yet the mechanism of dual loss is unexplained. We report 5 cases (World Health Organization grade III) in which metaphase cytogenetics identified a derivative chromosome consisting of what appears to be the whole arms of 1q and 19p forming a der(1;19)(q10;p10). Metaphase fluorescent in situ hybridization (FISH) confirmed the derivative chromosome was composed of 1q and 19p material in 3 cases; in 2 cases with few metaphases, FISH confirmed 19p material on the derivative chromosome. In all cases, interphase FISH showed net loss of 1p and 19q in 77{\%} to 92{\%} of cells, and microsatellite studies were consistent with 1p and 19q loss. We hypothesize the following: occurrence of a balanced whole-arm translocation between chromosomes 1 and 19 forming 2 derivative chromosomes, one composed of 1q and 19p, the other of 1p and 19q. Subsequent loss of the der(1;19)(p10;q10) then results in the simultaneous 1p and 19q loss observed in oligodendroglioma with retention of the der(1;19)(q10;p10) seen in these cases.",
keywords = "Brain tumor, Chromosome, Fluorescent in situ hybridization (FISH), Karyotype, Oligodendroglioma",
author = "Griffin, {Constance A.} and Peter Burger and Laura Morsberger and Raluca Yonescu and Sharon Swierczynski and Weingart, {Jon David} and Murphy, {Kathleen M.}",
year = "2006",
month = "10",
doi = "10.1097/01.jnen.0000235122.98052.8f",
language = "English (US)",
volume = "65",
pages = "988--994",
journal = "American Journal of Psychotherapy",
issn = "0002-9564",
publisher = "Lippincott Williams and Wilkins",
number = "10",

}

TY - JOUR

T1 - Identification of der(1;19)(q10;p10) in five oligodendrogliomas suggests mechanism of concurrent 1p and 19q loss

AU - Griffin, Constance A.

AU - Burger, Peter

AU - Morsberger, Laura

AU - Yonescu, Raluca

AU - Swierczynski, Sharon

AU - Weingart, Jon David

AU - Murphy, Kathleen M.

PY - 2006/10

Y1 - 2006/10

N2 - Deletions of portions of chromosomes 1p and 19q are closely associated with the oligodendroglioma histologic phenotype. In most cases, 1p and 19q are codeleted, yet the mechanism of dual loss is unexplained. We report 5 cases (World Health Organization grade III) in which metaphase cytogenetics identified a derivative chromosome consisting of what appears to be the whole arms of 1q and 19p forming a der(1;19)(q10;p10). Metaphase fluorescent in situ hybridization (FISH) confirmed the derivative chromosome was composed of 1q and 19p material in 3 cases; in 2 cases with few metaphases, FISH confirmed 19p material on the derivative chromosome. In all cases, interphase FISH showed net loss of 1p and 19q in 77% to 92% of cells, and microsatellite studies were consistent with 1p and 19q loss. We hypothesize the following: occurrence of a balanced whole-arm translocation between chromosomes 1 and 19 forming 2 derivative chromosomes, one composed of 1q and 19p, the other of 1p and 19q. Subsequent loss of the der(1;19)(p10;q10) then results in the simultaneous 1p and 19q loss observed in oligodendroglioma with retention of the der(1;19)(q10;p10) seen in these cases.

AB - Deletions of portions of chromosomes 1p and 19q are closely associated with the oligodendroglioma histologic phenotype. In most cases, 1p and 19q are codeleted, yet the mechanism of dual loss is unexplained. We report 5 cases (World Health Organization grade III) in which metaphase cytogenetics identified a derivative chromosome consisting of what appears to be the whole arms of 1q and 19p forming a der(1;19)(q10;p10). Metaphase fluorescent in situ hybridization (FISH) confirmed the derivative chromosome was composed of 1q and 19p material in 3 cases; in 2 cases with few metaphases, FISH confirmed 19p material on the derivative chromosome. In all cases, interphase FISH showed net loss of 1p and 19q in 77% to 92% of cells, and microsatellite studies were consistent with 1p and 19q loss. We hypothesize the following: occurrence of a balanced whole-arm translocation between chromosomes 1 and 19 forming 2 derivative chromosomes, one composed of 1q and 19p, the other of 1p and 19q. Subsequent loss of the der(1;19)(p10;q10) then results in the simultaneous 1p and 19q loss observed in oligodendroglioma with retention of the der(1;19)(q10;p10) seen in these cases.

KW - Brain tumor

KW - Chromosome

KW - Fluorescent in situ hybridization (FISH)

KW - Karyotype

KW - Oligodendroglioma

UR - http://www.scopus.com/inward/record.url?scp=33749471311&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33749471311&partnerID=8YFLogxK

U2 - 10.1097/01.jnen.0000235122.98052.8f

DO - 10.1097/01.jnen.0000235122.98052.8f

M3 - Article

VL - 65

SP - 988

EP - 994

JO - American Journal of Psychotherapy

JF - American Journal of Psychotherapy

SN - 0002-9564

IS - 10

ER -