Abstract
The phage surface display technique was used to identify Borrelia burgdorferi antigens. By affinity selection with immunoglobulin G from pooled sera of six Lyme borreliosis (LB) patients, the ribosomal protein L25 was identified. The diagnostic value of L25 was investigated by an enzyme-linked immunosorbent assay, using sera from 80 LB patients and 75 controls, and the use of the protein resulted in a specificity of 99% and a 23% sensitivity, which qualify L25 as a useful antigen when combined with others.
Original language | English (US) |
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Pages (from-to) | 3778-3780 |
Number of pages | 3 |
Journal | Journal of clinical microbiology |
Volume | 44 |
Issue number | 10 |
DOIs | |
State | Published - Oct 2006 |
Externally published | Yes |
ASJC Scopus subject areas
- Microbiology (medical)