Identification of biochemically distinct properties of the small ubiquitin-related modifier (SUMO) conjugation pathway in Plasmodium falciparum

Katherine Reiter, Debaditya Mukhopadhyay, Hong Zhang, Lauren E. Boucher, Nirbhay Kumar, Jürgen Bosch, Michael J. Matunis

Research output: Contribution to journalArticle

Abstract

Background: The sumoylation pathway is conserved in Plasmodium falciparum. Results: The small ubiquitin-related modifier (SUMO) E1 and E2 enzymes are not functionally interchangable between humans and the malaria parasite, P. falciparum. Conclusion: P. falciparum E1 and E2 interactions have significantly diverged from humans. Significance: Divergent E1 and E2 interaction could be exploited for the design of parasite specific inhibitors.

Original languageEnglish (US)
Pages (from-to)27724-27736
Number of pages13
JournalJournal of Biological Chemistry
Volume288
Issue number39
DOIs
StatePublished - Sep 27 2013

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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