Abstract
Background: The sumoylation pathway is conserved in Plasmodium falciparum. Results: The small ubiquitin-related modifier (SUMO) E1 and E2 enzymes are not functionally interchangable between humans and the malaria parasite, P. falciparum. Conclusion: P. falciparum E1 and E2 interactions have significantly diverged from humans. Significance: Divergent E1 and E2 interaction could be exploited for the design of parasite specific inhibitors.
Original language | English (US) |
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Pages (from-to) | 27724-27736 |
Number of pages | 13 |
Journal | Journal of Biological Chemistry |
Volume | 288 |
Issue number | 39 |
DOIs | |
State | Published - Sep 27 2013 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology