Identification of atherosclerotic lipid deposits by diffusion-weighted imaging

Ye Qiao, Itamar Ronen, Jason Viereck, Frederick L. Ruberg, James A. Hamilton

Research output: Contribution to journalArticle

Abstract

OBJECTIVES - The content and distribution of lipids is an important aspect of plaque vulnerability, but lipids are present within a heterogeneous environment, impeding detection by magnetic resonance imaging. Our goal was to achieve accurate detection of mobile lipids by a single magnetic resonance imaging sequence. METHODS AND RESULTS - Carotid endarectomy specimens (n=23) were imaged ex vivo at a high magnetic field (11.7 T) within 24 hours after surgery. Three contrast-weighted (T1W, T2W, and diffusion-weighted imaging [DWI]) image sequences were acquired and then coregistered with histological preparations for lipids (Oil red O and polarized light microscopy) and fibrous tissue (trichrome). Contrast-to-noise ratios were measured and compared for the 3 contrast weightings. Contrast-to-noise ratio measurement in regions identified as lipid versus fibrous tissue showed greater differences by DWI (4.5±0.63 versus 0.64±0.08; P

Original languageEnglish (US)
Pages (from-to)1440-1446
Number of pages7
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume27
Issue number6
DOIs
StatePublished - Jun 2007
Externally publishedYes

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Lipids
Noise
Magnetic Resonance Imaging
Polarization Microscopy
Magnetic Fields

Keywords

  • Atherosclerosis
  • Carotid arteries
  • Diffusion-weighted image
  • Lipids
  • MRI

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Identification of atherosclerotic lipid deposits by diffusion-weighted imaging. / Qiao, Ye; Ronen, Itamar; Viereck, Jason; Ruberg, Frederick L.; Hamilton, James A.

In: Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 27, No. 6, 06.2007, p. 1440-1446.

Research output: Contribution to journalArticle

Qiao, Ye ; Ronen, Itamar ; Viereck, Jason ; Ruberg, Frederick L. ; Hamilton, James A. / Identification of atherosclerotic lipid deposits by diffusion-weighted imaging. In: Arteriosclerosis, Thrombosis, and Vascular Biology. 2007 ; Vol. 27, No. 6. pp. 1440-1446.
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