Identification of an inherited form of Peyronie's disease with autosomal dominant inheritance and association with Dupuytren's contracture and histocompatibility B7 cross-reacting antigens

L. M. Nyberg, W. B. Bias, M. C. Hochberg, P. C. Walsh

Research output: Contribution to journalArticlepeer-review

Abstract

Peyronie's disease is an inflammatory disorder with no confirmed etiology. We have documented the familial transmission of the disease as an autosomal dominant trait in 3 pedigrees. The occurrence of Dupuyten's contracture in 7 of 9 (78 per cent) affected individuals, which is a significant increase over the average 10 per cent reported in sporadic cases, suggests that both of these fibrosing disorders are pleiotropic effects of the same gene in these families. Similarly, the histocompatibility B7 cross-reacting antigens were present in 90 per cent of the patients with Peyronie's disease. Additional studies, including careful family histories and histocompatibility antigen typing, are necessary to elucidate the role of histocompatibility antigens as a relative risk factor.

Original languageEnglish (US)
Pages (from-to)48-51
Number of pages4
JournalJournal of Urology
Volume128
Issue number1
DOIs
StatePublished - Jan 1 1982

ASJC Scopus subject areas

  • Urology

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