Identification of an epitope derived from human proteolipid protei nthat can induce autoreactive CD8+ cytotoxic T lymphocytes restricted by HLA-A3: Evidence for cross-reactivity with an environmental microorganism

Kiri Honma, Kenneth C. Parker, Kevin G. Becker, Henry F. McFarland, John E. Coligan, William E. Biddison

Research output: Contribution to journalArticlepeer-review

Abstract

The demyelination process that occurs in the central nervous system (CNS) of patients with multiple sclerosis (MS) is in part due to an inflammatory response in which CD4+ and CD8+ T cells and macrophages infiltrate white matter. In this study, we have identified a peptide sequence derived from the CNS-specific myelin protein proteolipid protein (PLP) which could bind to HLA-A3 and induce a HLA-A3-restricted CD8+ CTL response from HLA-A3+ donors. These PLP peptide-specific CTL could lyse HLA-A3+ target cells pulsed with a homologous peptide derived from the CRM1 protein of Saccharomyces cerevisiae. These findings demonstrate the immunogenic potential of a PLP-derived peptide for generation of autoreactive HLA-A3-restricted CD8+ CTL, and further show that these CTL can be activated by a peptide derived from a common environmental microorganism.

Original languageEnglish (US)
Pages (from-to)7-14
Number of pages8
JournalJournal of Neuroimmunology
Volume73
Issue number1-2
DOIs
StatePublished - Mar 1997
Externally publishedYes

Keywords

  • autoimmunity
  • cytotoxic T cells
  • HLA
  • molecular mimicry
  • multiple sclerosis

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

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