Abstract
The demyelination process that occurs in the central nervous system (CNS) of patients with multiple sclerosis (MS) is in part due to an inflammatory response in which CD4+ and CD8+ T cells and macrophages infiltrate white matter. In this study, we have identified a peptide sequence derived from the CNS-specific myelin protein proteolipid protein (PLP) which could bind to HLA-A3 and induce a HLA-A3-restricted CD8+ CTL response from HLA-A3+ donors. These PLP peptide-specific CTL could lyse HLA-A3+ target cells pulsed with a homologous peptide derived from the CRM1 protein of Saccharomyces cerevisiae. These findings demonstrate the immunogenic potential of a PLP-derived peptide for generation of autoreactive HLA-A3-restricted CD8+ CTL, and further show that these CTL can be activated by a peptide derived from a common environmental microorganism.
Original language | English (US) |
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Pages (from-to) | 7-14 |
Number of pages | 8 |
Journal | Journal of Neuroimmunology |
Volume | 73 |
Issue number | 1-2 |
DOIs | |
State | Published - Mar 1997 |
Externally published | Yes |
Keywords
- autoimmunity
- cytotoxic T cells
- HLA
- molecular mimicry
- multiple sclerosis
ASJC Scopus subject areas
- Immunology
- Clinical Neurology
- Immunology and Allergy
- Neurology