Identification of an amplified, highly expressed gene in a human glioma

Kenneth W Kinzler, Sandra H. Bigner, Darell D. Bigner, Jeffrey M. Trent, Martha L. Law, Stephen J. O'Brien, Albert J. Wong, Bert Vogelstein

Research output: Contribution to journalArticle

Abstract

A gene, termed gli, was identified that is amplified more than 50-fold in a malignant glioma. The gene is expressed at high levels in the original tumor and its derived cell line and is located at chromosome 12 position (q13 to q14.3). The gli gene is a member of a select group of cellular genes that are genetically altered in primary human tumors.

Original languageEnglish (US)
Pages (from-to)70-73
Number of pages4
JournalScience
Volume236
Issue number4797
StatePublished - 1987

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Glioma
Genes
Chromosomes, Human, Pair 12
Neoplasms
Cell Line

ASJC Scopus subject areas

  • General

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Kinzler, K. W., Bigner, S. H., Bigner, D. D., Trent, J. M., Law, M. L., O'Brien, S. J., ... Vogelstein, B. (1987). Identification of an amplified, highly expressed gene in a human glioma. Science, 236(4797), 70-73.

Identification of an amplified, highly expressed gene in a human glioma. / Kinzler, Kenneth W; Bigner, Sandra H.; Bigner, Darell D.; Trent, Jeffrey M.; Law, Martha L.; O'Brien, Stephen J.; Wong, Albert J.; Vogelstein, Bert.

In: Science, Vol. 236, No. 4797, 1987, p. 70-73.

Research output: Contribution to journalArticle

Kinzler, KW, Bigner, SH, Bigner, DD, Trent, JM, Law, ML, O'Brien, SJ, Wong, AJ & Vogelstein, B 1987, 'Identification of an amplified, highly expressed gene in a human glioma', Science, vol. 236, no. 4797, pp. 70-73.
Kinzler KW, Bigner SH, Bigner DD, Trent JM, Law ML, O'Brien SJ et al. Identification of an amplified, highly expressed gene in a human glioma. Science. 1987;236(4797):70-73.
Kinzler, Kenneth W ; Bigner, Sandra H. ; Bigner, Darell D. ; Trent, Jeffrey M. ; Law, Martha L. ; O'Brien, Stephen J. ; Wong, Albert J. ; Vogelstein, Bert. / Identification of an amplified, highly expressed gene in a human glioma. In: Science. 1987 ; Vol. 236, No. 4797. pp. 70-73.
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