Identification of a specific HLA DR2 Ia molecule as a restriction element for measles virus-specific HLA class II-restricted cytotoxic T cell clones

S. Jacobson, G. T. Nepom, J. R. Richert, W. E. Biddison, H. F. McFarland

Research output: Contribution to journalArticle

Abstract

By using a panel of HLA-D-defined subtypes of HLA-DR2 HCL with known β chain structural variabilities, we have demonstrated that HLA-DR2, OKT4+ cytotoxic T lymphocyte (CTL) clones specific for measles virus are apparently restricted to a distinct DR β chain. The presence of this DR β molecule correlated precisely with the susceptibility of measles virus-infected HLA-DR2 HCL to lysis by these CTL clones. These studies demonstrate that delineation of HLA-DR2 into various subgroups can have a functional significance that parallels the structural differences within the HLA-D region. These results are discussed in the context of the possible association of HLA class II-restricted, measles virus-specific CTL and multiple sclerosis.

Original languageEnglish (US)
Pages (from-to)263-268
Number of pages6
JournalJournal of Experimental Medicine
Volume161
Issue number1
DOIs
StatePublished - 1985
Externally publishedYes

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HLA-DR2 Antigen
Measles virus
Cytotoxic T-Lymphocytes
Clone Cells
HLA-D Antigens
T-Lymphocytes
Multiple Sclerosis

ASJC Scopus subject areas

  • Immunology

Cite this

Identification of a specific HLA DR2 Ia molecule as a restriction element for measles virus-specific HLA class II-restricted cytotoxic T cell clones. / Jacobson, S.; Nepom, G. T.; Richert, J. R.; Biddison, W. E.; McFarland, H. F.

In: Journal of Experimental Medicine, Vol. 161, No. 1, 1985, p. 263-268.

Research output: Contribution to journalArticle

Jacobson, S. ; Nepom, G. T. ; Richert, J. R. ; Biddison, W. E. ; McFarland, H. F. / Identification of a specific HLA DR2 Ia molecule as a restriction element for measles virus-specific HLA class II-restricted cytotoxic T cell clones. In: Journal of Experimental Medicine. 1985 ; Vol. 161, No. 1. pp. 263-268.
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