TY - JOUR
T1 - Identification of a specialized adenylyl cyclase that may mediate odorant detection
AU - Bakalyar, Heather A.
AU - Reed, Randall R.
PY - 1990
Y1 - 1990
N2 - The mammalian olfactory system may transduce odorant information via a G protein-mediated adenosine 3′,5′-monophosphate (cAMP) cascade. A newly discovered adenylyl cyclase, termed type III, has been cloned, and its expression was localized to olfactory neurons. The type III protein resides in the sensory neuronal cilia, which project into the nasal lumen and are accessible to airborne odorants. The enzymatic activity of the type III adenylyl cyclase appears to differ from nonsensory cyclases. The large difference seen between basal and stimulated activity for the type III enzyme could allow considerable modulation of the intracellular cAMP concentration. This property may represent one mechanism of achieving sensitivity in odorant perception.
AB - The mammalian olfactory system may transduce odorant information via a G protein-mediated adenosine 3′,5′-monophosphate (cAMP) cascade. A newly discovered adenylyl cyclase, termed type III, has been cloned, and its expression was localized to olfactory neurons. The type III protein resides in the sensory neuronal cilia, which project into the nasal lumen and are accessible to airborne odorants. The enzymatic activity of the type III adenylyl cyclase appears to differ from nonsensory cyclases. The large difference seen between basal and stimulated activity for the type III enzyme could allow considerable modulation of the intracellular cAMP concentration. This property may represent one mechanism of achieving sensitivity in odorant perception.
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U2 - 10.1126/science.2255909
DO - 10.1126/science.2255909
M3 - Article
C2 - 2255909
AN - SCOPUS:0025663760
SN - 0036-8075
VL - 250
SP - 1403
EP - 1406
JO - Science
JF - Science
IS - 4986
ER -