Identification of a recurring translocation site involving chromosome 6 in human malignant melanoma

J. M. Trent, F. H. Thompson, F. L. Meyskens

Research output: Contribution to journalArticle

Abstract

The recognition of recurring sites of chromosome change in human cancers has pinpointed the location in the genome of several important growth-regulatory sequences (e.g., cellular oncogenes). This report details the finding of a recurring translocation site involving the long arm of chromosome 6 (6q) in malignant melanoma. We have observed a translocation (t) between chromosomes 1 and 6 in five different cases of malignant metastatic melanoma. All five melanomas evidencing t(1;6) involved band regions 6q11-13, while two different regions of chromosome 1 (p22, q12-q21) were shown to be translocated to 6q. In reviewing previously published cases of melanoma, an additional two cases of t(1;6) and 13 cases of other translocations to 6q11-13 have been identified. Chromosome 6q contains several biologically important gene sequences including the proto-oncogenes ros, myb, and mas1. However, based on current mapping studies, the breakpoint of this translocation (6q11-13) is not within the region encoding these sequences. By analogy to other systems, molecular analysis of the translocation breakpoints may identify a gene(s) which plays a role in melanoma tumorigenesis.

Original languageEnglish (US)
Pages (from-to)420-423
Number of pages4
JournalCancer Research
Volume49
Issue number2
StatePublished - 1989
Externally publishedYes

Fingerprint

Chromosomes, Human, Pair 6
Melanoma
Chromosomes, Human, Pair 1
Chromosomes
Proto-Oncogenes
Oncogenes
Genes
Carcinogenesis
Genome
Growth
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Trent, J. M., Thompson, F. H., & Meyskens, F. L. (1989). Identification of a recurring translocation site involving chromosome 6 in human malignant melanoma. Cancer Research, 49(2), 420-423.

Identification of a recurring translocation site involving chromosome 6 in human malignant melanoma. / Trent, J. M.; Thompson, F. H.; Meyskens, F. L.

In: Cancer Research, Vol. 49, No. 2, 1989, p. 420-423.

Research output: Contribution to journalArticle

Trent, JM, Thompson, FH & Meyskens, FL 1989, 'Identification of a recurring translocation site involving chromosome 6 in human malignant melanoma', Cancer Research, vol. 49, no. 2, pp. 420-423.
Trent, J. M. ; Thompson, F. H. ; Meyskens, F. L. / Identification of a recurring translocation site involving chromosome 6 in human malignant melanoma. In: Cancer Research. 1989 ; Vol. 49, No. 2. pp. 420-423.
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