Identification of a primate cytomegalovirus group-common protein antigen

Diana Weiner, Wade Gibson

Research output: Contribution to journalArticlepeer-review

Abstract

A monospecific rabbit antiserum has been prepared to the denatured 145K major capsid protein of strain Colburn cytomegalovirus (CMV). Using this antiserum to analyze proteins electrophoretically transferred to nitrocellulose, it was found that infected cell preparations from all primate CMVs examined contain a single cross-reactive protein band that ranged in molecular weight from 144K to 153K, depending upon the isolate. No reactivity was observed when similar preparations of herpes simplex virus types 1 (HSV-1) and 2 (HSV-2), and herpes zoster virus (HZV) were tested, suggesting that this antiserum may be CMV group-specific. A second antiserum prepared to the denatured Colburn 66K matrix protein was found to be more selective in its reactivity toward other simian CMVs, and without reactivity to human CMV preparations.

Original languageEnglish (US)
Pages (from-to)182-191
Number of pages10
JournalVirology
Volume115
Issue number1
DOIs
StatePublished - Nov 1981

ASJC Scopus subject areas

  • Virology

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