TY - JOUR
T1 - Identification of a peptide recognized by five melanoma-specific human cytotoxic T cell lines
AU - Cox, Andrea L.
AU - Skipper, Jonathan
AU - Chen, Ye
AU - Henderson, Robert A.
AU - Darrow, Timothy L.
AU - Shabanowitz, Jeffrey
AU - Engelhard, Victor H.
AU - Hunt, Donald F.
AU - Slingluff, Craig L.
PY - 1994/4/29
Y1 - 1994/4/29
N2 - Of several thousand peptides presented by the major histocompatibility molecule HLA A2.1, at least nine are recognized by melanoma-specific cytotoxic T lymphocytes (CTLs). Tandem mass spectrometry was used to identify and to sequence one of these peptide epitopes. Melanoma-specific CTLs had an exceptionally high affinity for this nine-residue peptide, which reconstituted an epitope for CTL lines from each of five different melanoma patients tested. Recognition by multiple CTL lines suggests that this may be a promising candidate for use in peptide-based melanoma vaccines.
AB - Of several thousand peptides presented by the major histocompatibility molecule HLA A2.1, at least nine are recognized by melanoma-specific cytotoxic T lymphocytes (CTLs). Tandem mass spectrometry was used to identify and to sequence one of these peptide epitopes. Melanoma-specific CTLs had an exceptionally high affinity for this nine-residue peptide, which reconstituted an epitope for CTL lines from each of five different melanoma patients tested. Recognition by multiple CTL lines suggests that this may be a promising candidate for use in peptide-based melanoma vaccines.
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U2 - 10.1126/science.7513441
DO - 10.1126/science.7513441
M3 - Article
C2 - 7513441
AN - SCOPUS:0028304337
SN - 0036-8075
VL - 264
SP - 716
EP - 719
JO - Science
JF - Science
IS - 5159
ER -