Identification of a peptide recognized by five melanoma-specific human cytotoxic T cell lines

Andrea L. Cox, Jonathan Skipper, Ye Chen, Robert A. Henderson, Timothy L. Darrow, Jeffrey Shabanowitz, Victor H. Engelhard, Donald F. Hunt, Craig L. Slingluff

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Abstract

Of several thousand peptides presented by the major histocompatibility molecule HLA A2.1, at least nine are recognized by melanoma-specific cytotoxic T lymphocytes (CTLs). Tandem mass spectrometry was used to identify and to sequence one of these peptide epitopes. Melanoma-specific CTLs had an exceptionally high affinity for this nine-residue peptide, which reconstituted an epitope for CTL lines from each of five different melanoma patients tested. Recognition by multiple CTL lines suggests that this may be a promising candidate for use in peptide-based melanoma vaccines.

Original languageEnglish (US)
Pages (from-to)716-719
Number of pages4
JournalScience
Volume264
Issue number5159
DOIs
StatePublished - Apr 29 1994
Externally publishedYes

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    Cox, A. L., Skipper, J., Chen, Y., Henderson, R. A., Darrow, T. L., Shabanowitz, J., Engelhard, V. H., Hunt, D. F., & Slingluff, C. L. (1994). Identification of a peptide recognized by five melanoma-specific human cytotoxic T cell lines. Science, 264(5159), 716-719. https://doi.org/10.1126/science.7513441