Identification of a novel HLA-Cw*05 allele, Cw*0503

L. Q. Huang, T. Boon, Aline Van Pel

Research output: Contribution to journalShort survey

Abstract

HLA-Cw*05 is one of the least polymorphic subgroups of HLA-C; so far only two alleles, namely Cw*0501 and Cw*0502, have been reported. We report here the identification of a third allele, Cw*0503, in a Caucasian individual. Cw*0503 is closely related to Cw*0501 with only six nucleotide substitutions clustering over a fragment of 48 nucleotides at the beginning of exon 4. All these six substitutions at the same positions have been found only in HLA-B*44 alleles, suggesting that Cw*0503 is a result of recombination between Cw*0501 and one of B*44 alleles.

Original languageEnglish (US)
Pages (from-to)473-474
Number of pages2
JournalTissue Antigens
Volume55
Issue number5
DOIs
StatePublished - 2000
Externally publishedYes

Fingerprint

Alleles
Nucleotides
HLA-C Antigens
HLA-B Antigens
Genetic Recombination
Cluster Analysis
Exons

Keywords

  • cDNA cloning
  • HLA-Cw*0503
  • Nucleotide sequencing

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Genetics

Cite this

Identification of a novel HLA-Cw*05 allele, Cw*0503. / Huang, L. Q.; Boon, T.; Van Pel, Aline.

In: Tissue Antigens, Vol. 55, No. 5, 2000, p. 473-474.

Research output: Contribution to journalShort survey

Huang, L. Q. ; Boon, T. ; Van Pel, Aline. / Identification of a novel HLA-Cw*05 allele, Cw*0503. In: Tissue Antigens. 2000 ; Vol. 55, No. 5. pp. 473-474.
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N2 - HLA-Cw*05 is one of the least polymorphic subgroups of HLA-C; so far only two alleles, namely Cw*0501 and Cw*0502, have been reported. We report here the identification of a third allele, Cw*0503, in a Caucasian individual. Cw*0503 is closely related to Cw*0501 with only six nucleotide substitutions clustering over a fragment of 48 nucleotides at the beginning of exon 4. All these six substitutions at the same positions have been found only in HLA-B*44 alleles, suggesting that Cw*0503 is a result of recombination between Cw*0501 and one of B*44 alleles.

AB - HLA-Cw*05 is one of the least polymorphic subgroups of HLA-C; so far only two alleles, namely Cw*0501 and Cw*0502, have been reported. We report here the identification of a third allele, Cw*0503, in a Caucasian individual. Cw*0503 is closely related to Cw*0501 with only six nucleotide substitutions clustering over a fragment of 48 nucleotides at the beginning of exon 4. All these six substitutions at the same positions have been found only in HLA-B*44 alleles, suggesting that Cw*0503 is a result of recombination between Cw*0501 and one of B*44 alleles.

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KW - Nucleotide sequencing

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