Identification of a novel Drosophila SMAD on the X chromosome

Katya D. Henderson, Deborah J. Andrew

Research output: Contribution to journalArticlepeer-review

Abstract

TGF-β signaling from the cell surface to the nucleus is mediated by the SMAD family of proteins, which have been grouped into three classes based upon sequence identity and function. Receptor-regulated, or pathway-restricted, SMADs (R-SMADs) are phosphorylated by ligand-specific serine/threonine kinase receptors. Phosphorylated R-SMADs oligomerize with the coactivating, or shared, SMAD (Co-SMAD) mediator and translocate to the nucleus where the complex directs transcription of downstream target genes. Inhibitory SMADs (I-SMADs) block receptor-mediated phosphorylation of R-SMADs. In Drosophila, one member of each class of SMAD has been reported: MAD, an R-SMAD, MEDEA, a Co-SMAD, and DAD, an I-SMAD. Here, we report the first identification of a novel Drosophila R-SMAD, which we have named Smox for Smad on X. We have localized the Smox gene to a specific interval on the X chromosome and shown that Smox is transcribed throughout development.

Original languageEnglish (US)
Pages (from-to)195-201
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume252
Issue number1
DOIs
StatePublished - Nov 9 1998

Keywords

  • ACTIVIN
  • DPP
  • Drosophila
  • SMADs

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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