Identification of a novel DR4 allele, DRB1*0442

T. A. Dunn; B. A. Iglehart; M. S. Leffell

doi:10.1034/j.1399-0039.2001.580311.x

Identification of a novel DR4 allele, DRB1*0442

T. A. Dunn, B. A. Iglehart, M. S. Leffell

School of Medicine

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

A new DRB1 allele encoding DR4, DRB1*0442, was identified in three Caucasian siblings by reverse in-line hybridization and defined by sequencing based typing. The DRB1*0442 allele differs from DRB1*0404 by a single nucleotide at position 227 (T→A) of codon 47 in exon 2. At the amino acid level, this substitution results in a change from tyrosine to phenylalanine. Serologically, the new allele appears to retain the DR4 antigenicity; however, this substitution may affect peptide-binding specificity.

Original language	English (US)
Pages (from-to)	198-200
Number of pages	3
Journal	Tissue Antigens
Volume	58
Issue number	3
DOIs	https://doi.org/10.1034/j.1399-0039.2001.580311.x
State	Published - 2001

Keywords

DR4 alleles
DRB1*0442

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Biochemistry
Genetics

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10.1034/j.1399-0039.2001.580311.x

Cite this

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title = "Identification of a novel DR4 allele, DRB1*0442",

abstract = "A new DRB1 allele encoding DR4, DRB1*0442, was identified in three Caucasian siblings by reverse in-line hybridization and defined by sequencing based typing. The DRB1*0442 allele differs from DRB1*0404 by a single nucleotide at position 227 (T→A) of codon 47 in exon 2. At the amino acid level, this substitution results in a change from tyrosine to phenylalanine. Serologically, the new allele appears to retain the DR4 antigenicity; however, this substitution may affect peptide-binding specificity.",

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AU - Dunn, T. A.

AU - Iglehart, B. A.

AU - Leffell, M. S.

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Y1 - 2001

N2 - A new DRB1 allele encoding DR4, DRB1*0442, was identified in three Caucasian siblings by reverse in-line hybridization and defined by sequencing based typing. The DRB1*0442 allele differs from DRB1*0404 by a single nucleotide at position 227 (T→A) of codon 47 in exon 2. At the amino acid level, this substitution results in a change from tyrosine to phenylalanine. Serologically, the new allele appears to retain the DR4 antigenicity; however, this substitution may affect peptide-binding specificity.

AB - A new DRB1 allele encoding DR4, DRB1*0442, was identified in three Caucasian siblings by reverse in-line hybridization and defined by sequencing based typing. The DRB1*0442 allele differs from DRB1*0404 by a single nucleotide at position 227 (T→A) of codon 47 in exon 2. At the amino acid level, this substitution results in a change from tyrosine to phenylalanine. Serologically, the new allele appears to retain the DR4 antigenicity; however, this substitution may affect peptide-binding specificity.

KW - DR4 alleles

KW - DRB10442

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Identification of a novel DR4 allele, DRB1*0442

Abstract

Keywords

ASJC Scopus subject areas

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