Identification of a novel DR4 allele, DRB1*0442

T. A. Dunn, B. A. Iglehart, M. S. Leffell

Research output: Contribution to journalArticlepeer-review

Abstract

A new DRB1 allele encoding DR4, DRB1*0442, was identified in three Caucasian siblings by reverse in-line hybridization and defined by sequencing based typing. The DRB1*0442 allele differs from DRB1*0404 by a single nucleotide at position 227 (T→A) of codon 47 in exon 2. At the amino acid level, this substitution results in a change from tyrosine to phenylalanine. Serologically, the new allele appears to retain the DR4 antigenicity; however, this substitution may affect peptide-binding specificity.

Original languageEnglish (US)
Pages (from-to)198-200
Number of pages3
JournalTissue Antigens
Volume58
Issue number3
DOIs
StatePublished - 2001

Keywords

  • DR4 alleles
  • DRB1*0442

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Biochemistry
  • Genetics

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