Identification of a novel DR4 allele, DRB1*0442

T. A. Dunn, B. A. Iglehart, M. S. Leffell

Research output: Contribution to journalArticle

Abstract

A new DRB1 allele encoding DR4, DRB1*0442, was identified in three Caucasian siblings by reverse in-line hybridization and defined by sequencing based typing. The DRB1*0442 allele differs from DRB1*0404 by a single nucleotide at position 227 (T→A) of codon 47 in exon 2. At the amino acid level, this substitution results in a change from tyrosine to phenylalanine. Serologically, the new allele appears to retain the DR4 antigenicity; however, this substitution may affect peptide-binding specificity.

Original languageEnglish (US)
Pages (from-to)198-200
Number of pages3
JournalTissue Antigens
Volume58
Issue number3
DOIs
StatePublished - 2001

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Alleles
Phenylalanine
Codon
Tyrosine
Exons
Nucleotides
Amino Acids
Peptides

Keywords

  • DR4 alleles
  • DRB1*0442

ASJC Scopus subject areas

  • Immunology
  • Cell Biology

Cite this

Dunn, T. A., Iglehart, B. A., & Leffell, M. S. (2001). Identification of a novel DR4 allele, DRB1*0442. Tissue Antigens, 58(3), 198-200. https://doi.org/10.1034/j.1399-0039.2001.580311.x

Identification of a novel DR4 allele, DRB1*0442. / Dunn, T. A.; Iglehart, B. A.; Leffell, M. S.

In: Tissue Antigens, Vol. 58, No. 3, 2001, p. 198-200.

Research output: Contribution to journalArticle

Dunn, TA, Iglehart, BA & Leffell, MS 2001, 'Identification of a novel DR4 allele, DRB1*0442', Tissue Antigens, vol. 58, no. 3, pp. 198-200. https://doi.org/10.1034/j.1399-0039.2001.580311.x
Dunn, T. A. ; Iglehart, B. A. ; Leffell, M. S. / Identification of a novel DR4 allele, DRB1*0442. In: Tissue Antigens. 2001 ; Vol. 58, No. 3. pp. 198-200.
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