Identification of a new prostate cancer susceptibility locus on chromosome 8q24

Meredith Yeager, Nilanjan Chatterjee, Julia Ciampa, Kevin B. Jacobs, Jesus Gonzalez-Bosquet, Richard B. Hayes, Peter Kraft, Sholom Wacholder, Nick Orr, Sonja Berndt, Kai Yu, Amy Hutchinson, Zhaoming Wang, Laufey Amundadottir, Heather Spencer Feigelson, Michael J. Thun, W. Ryan Diver, Demetrius Albanes, Jarmo Virtamo, Stephanie WeinsteinFredrick R. Schumacher, Geraldine Cancel-Tassin, Olivier Cussenot, Antoine Valeri, Gerald L. Andriole, E. David Crawford, Christopher A. Haiman, Brian Henderson, Laurence Kolonel, Loic Le Marchand, Afshan Siddiq, Elio Riboli, Timothy J. Key, Rudolf Kaaks, William Isaacs, Sarah Isaacs, Kathleen E. Wiley, Henrik Gronberg, Fredrik Wiklund, Pär Stattin, Jianfeng Xu, S. Lilly Zheng, Jielin Sun, Lars J. Vatten, Kristian Hveem, Merethe Kumle, Margaret Tucker, Daniela S. Gerhard, Robert N. Hoover, Joseph F. Fraumeni, David J. Hunter, Gilles Thomas, Stephen J. Chanock

Research output: Contribution to journalArticle

Abstract

We report a genome-wide association study in 10,286 cases and 9,135 controls of European ancestry in the Cancer Genetic Markers of Susceptibility (CGEMS) initiative. We identify a new association with prostate cancer risk on chromosome 8q24 (rs620861, P = 1.3 × 10 10, heterozygote OR = 1.17, 95% CI 1.10-1.24; homozygote OR = 1.33, 95% CI 1.21-1.45). This defines a new locus associated with prostate cancer susceptibility on 8q24.

Original languageEnglish (US)
Pages (from-to)1055-1057
Number of pages3
JournalNature genetics
Volume41
Issue number10
DOIs
StatePublished - Oct 2009

ASJC Scopus subject areas

  • Genetics

Fingerprint Dive into the research topics of 'Identification of a new prostate cancer susceptibility locus on chromosome 8q24'. Together they form a unique fingerprint.

  • Cite this

    Yeager, M., Chatterjee, N., Ciampa, J., Jacobs, K. B., Gonzalez-Bosquet, J., Hayes, R. B., Kraft, P., Wacholder, S., Orr, N., Berndt, S., Yu, K., Hutchinson, A., Wang, Z., Amundadottir, L., Feigelson, H. S., Thun, M. J., Diver, W. R., Albanes, D., Virtamo, J., ... Chanock, S. J. (2009). Identification of a new prostate cancer susceptibility locus on chromosome 8q24. Nature genetics, 41(10), 1055-1057. https://doi.org/10.1038/ng.444