Identification of a new prostate cancer susceptibility locus on chromosome 8q24

Meredith Yeager; Nilanjan Chatterjee; Julia Ciampa; Kevin B. Jacobs; Jesus Gonzalez-Bosquet; Richard B. Hayes; Peter Kraft; Sholom Wacholder; Nick Orr; Sonja Berndt; Kai Yu; Amy Hutchinson; Zhaoming Wang; Laufey Amundadottir; Heather Spencer Feigelson; Michael J. Thun; W. Ryan Diver; Demetrius Albanes; Jarmo Virtamo; Stephanie Weinstein; Fredrick R. Schumacher; Geraldine Cancel-Tassin; Olivier Cussenot; Antoine Valeri; Gerald L. Andriole; E. David Crawford; Christopher A. Haiman; Brian Henderson; Laurence Kolonel; Loic Le Marchand; Afshan Siddiq; Elio Riboli; Timothy J. Key; Rudolf Kaaks; William Isaacs; Sarah Isaacs; Kathleen E. Wiley; Henrik Gronberg; Fredrik Wiklund; Pär Stattin; Jianfeng Xu; S. Lilly Zheng; Jielin Sun; Lars J. Vatten; Kristian Hveem; Merethe Kumle; Margaret Tucker; Daniela S. Gerhard; Robert N. Hoover; Joseph F. Fraumeni; David J. Hunter; Gilles Thomas; Stephen J. Chanock

doi:10.1038/ng.444

Identification of a new prostate cancer susceptibility locus on chromosome 8q24

Meredith Yeager, Nilanjan Chatterjee, Julia Ciampa, Kevin B. Jacobs, Jesus Gonzalez-Bosquet, Richard B. Hayes, Peter Kraft, Sholom Wacholder, Nick Orr, Sonja Berndt, Kai Yu, Amy Hutchinson, Zhaoming Wang, Laufey Amundadottir, Heather Spencer Feigelson, Michael J. Thun, W. Ryan Diver, Demetrius Albanes, Jarmo Virtamo, Stephanie WeinsteinFredrick R. Schumacher, Geraldine Cancel-Tassin, Olivier Cussenot, Antoine Valeri, Gerald L. Andriole, E. David Crawford, Christopher A. Haiman, Brian Henderson, Laurence Kolonel, Loic Le Marchand, Afshan Siddiq, Elio Riboli, Timothy J. Key, Rudolf Kaaks, William Isaacs, Sarah Isaacs, Kathleen E. Wiley, Henrik Gronberg, Fredrik Wiklund, Pär Stattin, Jianfeng Xu, S. Lilly Zheng, Jielin Sun, Lars J. Vatten, Kristian Hveem, Merethe Kumle, Margaret Tucker, Daniela S. Gerhard, Robert N. Hoover, Joseph F. Fraumeni, David J. Hunter, Gilles Thomas, Stephen J. Chanock

School of Medicine

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Abstract

We report a genome-wide association study in 10,286 cases and 9,135 controls of European ancestry in the Cancer Genetic Markers of Susceptibility (CGEMS) initiative. We identify a new association with prostate cancer risk on chromosome 8q24 (rs620861, P = 1.3 × 10 10, heterozygote OR = 1.17, 95% CI 1.10-1.24; homozygote OR = 1.33, 95% CI 1.21-1.45). This defines a new locus associated with prostate cancer susceptibility on 8q24.

Original language	English (US)
Pages (from-to)	1055-1057
Number of pages	3
Journal	Nature genetics
Volume	41
Issue number	10
DOIs	https://doi.org/10.1038/ng.444
State	Published - Oct 2009

ASJC Scopus subject areas

Genetics

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Yeager, M., Chatterjee, N., Ciampa, J., Jacobs, K. B., Gonzalez-Bosquet, J., Hayes, R. B., Kraft, P., Wacholder, S., Orr, N., Berndt, S., Yu, K., Hutchinson, A., Wang, Z., Amundadottir, L., Feigelson, H. S., Thun, M. J., Diver, W. R., Albanes, D., Virtamo, J., ... Chanock, S. J. (2009). Identification of a new prostate cancer susceptibility locus on chromosome 8q24. Nature genetics, 41(10), 1055-1057. https://doi.org/10.1038/ng.444

Yeager, M, Chatterjee, N, Ciampa, J, Jacobs, KB, Gonzalez-Bosquet, J, Hayes, RB, Kraft, P, Wacholder, S, Orr, N, Berndt, S, Yu, K, Hutchinson, A, Wang, Z, Amundadottir, L, Feigelson, HS, Thun, MJ, Diver, WR, Albanes, D, Virtamo, J, Weinstein, S, Schumacher, FR, Cancel-Tassin, G, Cussenot, O, Valeri, A, Andriole, GL, Crawford, ED, Haiman, CA, Henderson, B, Kolonel, L, Le Marchand, L, Siddiq, A, Riboli, E, Key, TJ, Kaaks, R, Isaacs, W, Isaacs, S, Wiley, KE, Gronberg, H, Wiklund, F, Stattin, P, Xu, J, Zheng, SL, Sun, J, Vatten, LJ, Hveem, K, Kumle, M, Tucker, M, Gerhard, DS, Hoover, RN, Fraumeni, JF, Hunter, DJ, Thomas, G & Chanock, SJ 2009, 'Identification of a new prostate cancer susceptibility locus on chromosome 8q24', Nature genetics, vol. 41, no. 10, pp. 1055-1057. https://doi.org/10.1038/ng.444

@article{33c74f506b5a402eb88e501b0a44345f,

title = "Identification of a new prostate cancer susceptibility locus on chromosome 8q24",

abstract = "We report a genome-wide association study in 10,286 cases and 9,135 controls of European ancestry in the Cancer Genetic Markers of Susceptibility (CGEMS) initiative. We identify a new association with prostate cancer risk on chromosome 8q24 (rs620861, P = 1.3 × 10 10, heterozygote OR = 1.17, 95% CI 1.10-1.24; homozygote OR = 1.33, 95% CI 1.21-1.45). This defines a new locus associated with prostate cancer susceptibility on 8q24.",

author = "Meredith Yeager and Nilanjan Chatterjee and Julia Ciampa and Jacobs, {Kevin B.} and Jesus Gonzalez-Bosquet and Hayes, {Richard B.} and Peter Kraft and Sholom Wacholder and Nick Orr and Sonja Berndt and Kai Yu and Amy Hutchinson and Zhaoming Wang and Laufey Amundadottir and Feigelson, {Heather Spencer} and Thun, {Michael J.} and Diver, {W. Ryan} and Demetrius Albanes and Jarmo Virtamo and Stephanie Weinstein and Schumacher, {Fredrick R.} and Geraldine Cancel-Tassin and Olivier Cussenot and Antoine Valeri and Andriole, {Gerald L.} and Crawford, {E. David} and Haiman, {Christopher A.} and Brian Henderson and Laurence Kolonel and {Le Marchand}, Loic and Afshan Siddiq and Elio Riboli and Key, {Timothy J.} and Rudolf Kaaks and William Isaacs and Sarah Isaacs and Wiley, {Kathleen E.} and Henrik Gronberg and Fredrik Wiklund and P{\"a}r Stattin and Jianfeng Xu and Zheng, {S. Lilly} and Jielin Sun and Vatten, {Lars J.} and Kristian Hveem and Merethe Kumle and Margaret Tucker and Gerhard, {Daniela S.} and Hoover, {Robert N.} and Fraumeni, {Joseph F.} and Hunter, {David J.} and Gilles Thomas and Chanock, {Stephen J.}",

note = "Funding Information: This project was funded in part using grants CA129684 to J.X. and CA131338 to S.L.Z. This project was funded in whole or in part with federal funds from the NCI, National Institutes of Health (NIH), under Contract No. HHSN261200800001E. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services (DHHS), nor does mention of trade names, commercial products, or organizations imply endorsement by the US Government.",

year = "2009",

month = oct,

doi = "10.1038/ng.444",

language = "English (US)",

volume = "41",

pages = "1055--1057",

journal = "Nature genetics",

issn = "1061-4036",

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T1 - Identification of a new prostate cancer susceptibility locus on chromosome 8q24

AU - Yeager, Meredith

AU - Chatterjee, Nilanjan

AU - Ciampa, Julia

AU - Jacobs, Kevin B.

AU - Gonzalez-Bosquet, Jesus

AU - Hayes, Richard B.

AU - Kraft, Peter

AU - Wacholder, Sholom

AU - Orr, Nick

AU - Berndt, Sonja

AU - Yu, Kai

AU - Hutchinson, Amy

AU - Wang, Zhaoming

AU - Amundadottir, Laufey

AU - Feigelson, Heather Spencer

AU - Thun, Michael J.

AU - Diver, W. Ryan

AU - Albanes, Demetrius

AU - Virtamo, Jarmo

AU - Weinstein, Stephanie

AU - Schumacher, Fredrick R.

AU - Cancel-Tassin, Geraldine

AU - Cussenot, Olivier

AU - Valeri, Antoine

AU - Andriole, Gerald L.

AU - Crawford, E. David

AU - Haiman, Christopher A.

AU - Henderson, Brian

AU - Kolonel, Laurence

AU - Le Marchand, Loic

AU - Siddiq, Afshan

AU - Riboli, Elio

AU - Key, Timothy J.

AU - Kaaks, Rudolf

AU - Isaacs, William

AU - Isaacs, Sarah

AU - Wiley, Kathleen E.

AU - Gronberg, Henrik

AU - Wiklund, Fredrik

AU - Stattin, Pär

AU - Xu, Jianfeng

AU - Zheng, S. Lilly

AU - Sun, Jielin

AU - Vatten, Lars J.

AU - Hveem, Kristian

AU - Kumle, Merethe

AU - Tucker, Margaret

AU - Gerhard, Daniela S.

AU - Hoover, Robert N.

AU - Fraumeni, Joseph F.

AU - Hunter, David J.

AU - Thomas, Gilles

AU - Chanock, Stephen J.

N1 - Funding Information: This project was funded in part using grants CA129684 to J.X. and CA131338 to S.L.Z. This project was funded in whole or in part with federal funds from the NCI, National Institutes of Health (NIH), under Contract No. HHSN261200800001E. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services (DHHS), nor does mention of trade names, commercial products, or organizations imply endorsement by the US Government.

PY - 2009/10

Y1 - 2009/10

N2 - We report a genome-wide association study in 10,286 cases and 9,135 controls of European ancestry in the Cancer Genetic Markers of Susceptibility (CGEMS) initiative. We identify a new association with prostate cancer risk on chromosome 8q24 (rs620861, P = 1.3 × 10 10, heterozygote OR = 1.17, 95% CI 1.10-1.24; homozygote OR = 1.33, 95% CI 1.21-1.45). This defines a new locus associated with prostate cancer susceptibility on 8q24.

AB - We report a genome-wide association study in 10,286 cases and 9,135 controls of European ancestry in the Cancer Genetic Markers of Susceptibility (CGEMS) initiative. We identify a new association with prostate cancer risk on chromosome 8q24 (rs620861, P = 1.3 × 10 10, heterozygote OR = 1.17, 95% CI 1.10-1.24; homozygote OR = 1.33, 95% CI 1.21-1.45). This defines a new locus associated with prostate cancer susceptibility on 8q24.

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SP - 1055

EP - 1057

JO - Nature genetics

JF - Nature genetics

IS - 10

ER -

Identification of a new prostate cancer susceptibility locus on chromosome 8q24

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