Identification of a new prostate cancer susceptibility locus on chromosome 8q24

Meredith Yeager, Nilanjan Chatterjee, Julia Ciampa, Kevin B. Jacobs, Jesus Gonzalez-Bosquet, Richard B. Hayes, Peter Kraft, Sholom Wacholder, Nick Orr, Sonja Berndt, Kai Yu, Amy Hutchinson, Zhaoming Wang, Laufey Amundadottir, Heather Spencer Feigelson, Michael J. Thun, W. Ryan Diver, Demetrius Albanes, Jarmo Virtamo, Stephanie Weinstein & 33 others Fredrick R. Schumacher, Geraldine Cancel-Tassin, Olivier Cussenot, Antoine Valeri, Gerald L. Andriole, E. David Crawford, Christopher A. Haiman, Brian Henderson, Laurence Kolonel, Loic Le Marchand, Afshan Siddiq, Elio Riboli, Timothy J. Key, Rudolf Kaaks, William B Isaacs, Sarah Isaacs, Kathleen E. Wiley, Henrik Gronberg, Fredrik Wiklund, Pär Stattin, Jianfeng Xu, S. Lilly Zheng, Jielin Sun, Lars J. Vatten, Kristian Hveem, Merethe Kumle, Margaret Tucker, Daniela S. Gerhard, Robert N. Hoover, Joseph F. Fraumeni, David J. Hunter, Gilles Thomas, Stephen J. Chanock

Research output: Contribution to journalArticle

Abstract

We report a genome-wide association study in 10,286 cases and 9,135 controls of European ancestry in the Cancer Genetic Markers of Susceptibility (CGEMS) initiative. We identify a new association with prostate cancer risk on chromosome 8q24 (rs620861, P = 1.3 × 10 10, heterozygote OR = 1.17, 95% CI 1.10-1.24; homozygote OR = 1.33, 95% CI 1.21-1.45). This defines a new locus associated with prostate cancer susceptibility on 8q24.

Original languageEnglish (US)
Pages (from-to)1055-1057
Number of pages3
JournalNature Genetics
Volume41
Issue number10
DOIs
StatePublished - Oct 2009

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Prostatic Neoplasms
Chromosomes
Genome-Wide Association Study
Homozygote
Genetic Predisposition to Disease
Heterozygote
Genetic Markers
Neoplasms

ASJC Scopus subject areas

  • Genetics

Cite this

Yeager, M., Chatterjee, N., Ciampa, J., Jacobs, K. B., Gonzalez-Bosquet, J., Hayes, R. B., ... Chanock, S. J. (2009). Identification of a new prostate cancer susceptibility locus on chromosome 8q24. Nature Genetics, 41(10), 1055-1057. https://doi.org/10.1038/ng.444

Identification of a new prostate cancer susceptibility locus on chromosome 8q24. / Yeager, Meredith; Chatterjee, Nilanjan; Ciampa, Julia; Jacobs, Kevin B.; Gonzalez-Bosquet, Jesus; Hayes, Richard B.; Kraft, Peter; Wacholder, Sholom; Orr, Nick; Berndt, Sonja; Yu, Kai; Hutchinson, Amy; Wang, Zhaoming; Amundadottir, Laufey; Feigelson, Heather Spencer; Thun, Michael J.; Diver, W. Ryan; Albanes, Demetrius; Virtamo, Jarmo; Weinstein, Stephanie; Schumacher, Fredrick R.; Cancel-Tassin, Geraldine; Cussenot, Olivier; Valeri, Antoine; Andriole, Gerald L.; Crawford, E. David; Haiman, Christopher A.; Henderson, Brian; Kolonel, Laurence; Le Marchand, Loic; Siddiq, Afshan; Riboli, Elio; Key, Timothy J.; Kaaks, Rudolf; Isaacs, William B; Isaacs, Sarah; Wiley, Kathleen E.; Gronberg, Henrik; Wiklund, Fredrik; Stattin, Pär; Xu, Jianfeng; Zheng, S. Lilly; Sun, Jielin; Vatten, Lars J.; Hveem, Kristian; Kumle, Merethe; Tucker, Margaret; Gerhard, Daniela S.; Hoover, Robert N.; Fraumeni, Joseph F.; Hunter, David J.; Thomas, Gilles; Chanock, Stephen J.

In: Nature Genetics, Vol. 41, No. 10, 10.2009, p. 1055-1057.

Research output: Contribution to journalArticle

Yeager, M, Chatterjee, N, Ciampa, J, Jacobs, KB, Gonzalez-Bosquet, J, Hayes, RB, Kraft, P, Wacholder, S, Orr, N, Berndt, S, Yu, K, Hutchinson, A, Wang, Z, Amundadottir, L, Feigelson, HS, Thun, MJ, Diver, WR, Albanes, D, Virtamo, J, Weinstein, S, Schumacher, FR, Cancel-Tassin, G, Cussenot, O, Valeri, A, Andriole, GL, Crawford, ED, Haiman, CA, Henderson, B, Kolonel, L, Le Marchand, L, Siddiq, A, Riboli, E, Key, TJ, Kaaks, R, Isaacs, WB, Isaacs, S, Wiley, KE, Gronberg, H, Wiklund, F, Stattin, P, Xu, J, Zheng, SL, Sun, J, Vatten, LJ, Hveem, K, Kumle, M, Tucker, M, Gerhard, DS, Hoover, RN, Fraumeni, JF, Hunter, DJ, Thomas, G & Chanock, SJ 2009, 'Identification of a new prostate cancer susceptibility locus on chromosome 8q24', Nature Genetics, vol. 41, no. 10, pp. 1055-1057. https://doi.org/10.1038/ng.444
Yeager M, Chatterjee N, Ciampa J, Jacobs KB, Gonzalez-Bosquet J, Hayes RB et al. Identification of a new prostate cancer susceptibility locus on chromosome 8q24. Nature Genetics. 2009 Oct;41(10):1055-1057. https://doi.org/10.1038/ng.444
Yeager, Meredith ; Chatterjee, Nilanjan ; Ciampa, Julia ; Jacobs, Kevin B. ; Gonzalez-Bosquet, Jesus ; Hayes, Richard B. ; Kraft, Peter ; Wacholder, Sholom ; Orr, Nick ; Berndt, Sonja ; Yu, Kai ; Hutchinson, Amy ; Wang, Zhaoming ; Amundadottir, Laufey ; Feigelson, Heather Spencer ; Thun, Michael J. ; Diver, W. Ryan ; Albanes, Demetrius ; Virtamo, Jarmo ; Weinstein, Stephanie ; Schumacher, Fredrick R. ; Cancel-Tassin, Geraldine ; Cussenot, Olivier ; Valeri, Antoine ; Andriole, Gerald L. ; Crawford, E. David ; Haiman, Christopher A. ; Henderson, Brian ; Kolonel, Laurence ; Le Marchand, Loic ; Siddiq, Afshan ; Riboli, Elio ; Key, Timothy J. ; Kaaks, Rudolf ; Isaacs, William B ; Isaacs, Sarah ; Wiley, Kathleen E. ; Gronberg, Henrik ; Wiklund, Fredrik ; Stattin, Pär ; Xu, Jianfeng ; Zheng, S. Lilly ; Sun, Jielin ; Vatten, Lars J. ; Hveem, Kristian ; Kumle, Merethe ; Tucker, Margaret ; Gerhard, Daniela S. ; Hoover, Robert N. ; Fraumeni, Joseph F. ; Hunter, David J. ; Thomas, Gilles ; Chanock, Stephen J. / Identification of a new prostate cancer susceptibility locus on chromosome 8q24. In: Nature Genetics. 2009 ; Vol. 41, No. 10. pp. 1055-1057.
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