Identification of a meiotic prophase-specific nuclear matrix protein in the rat.

A. Behal, K. Prakash, M. R. Rao

Research output: Contribution to journalArticlepeer-review

Abstract

We have identified a 110-kDa pI 5.6 phosphoprotein with DNA binding properties in the rat pachytene spermatocyte nuclear matrix. By immunoblotting and indirect immunofluorescence assays using polyclonal antibodies against the 110-kDa protein, we observed that it was germ cell nuclear matrix specific, more prominent in pachytene spermatocytes compared to premeiotic spermatogonia or postmeiotic round spermatids, and present in rat oocytes and in germ cells of mouse and monkey. We propose that this protein could play an important role in the meiotic process.

Original languageEnglish (US)
Pages (from-to)10898-10902
Number of pages5
JournalJournal of Biological Chemistry
Volume262
Issue number22
StatePublished - Aug 5 1987

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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