Identification of a large molecular weight peptide associated with a tetrodotoxin binding protein from the electroplax of Electrophorus electricus

William Agnew; Anne C. Moore; Simon R. Levinson; Michael A. Raftery

doi:10.1016/0006-291X(80)90782-2

Identification of a large molecular weight peptide associated with a tetrodotoxin binding protein from the electroplax of Electrophorus electricus

William Agnew, Anne C. Moore, Simon R. Levinson, Michael A. Raftery

Research output: Contribution to journal › Article

Abstract

We have previously described the purification of a tetrodotoxin binding protein from the electroplax of Electrophorus electricus. The preparation consisted of three peptides of M_r ∼ 46,000, 59,000 and ∼ 300,000 daltons. Further investigation has now shown that the large peptide of M_r ∼ 260,000 daltons is part of the tetrodotoxin binding component of the voltage-sensitive sodium channel.

Original language	English (US)
Pages (from-to)	860-866
Number of pages	7
Journal	Biochemical and Biophysical Research Communications
Volume	92
Issue number	3
DOIs	https://doi.org/10.1016/0006-291X(80)90782-2
State	Published - Feb 12 1980
Externally published	Yes

Fingerprint

Electrophorus

Molecular Weight

Molecular weight

Peptides

Sodium Channels

Tetrodotoxin

Purification

Electric potential

tetrodotoxin-binding protein

ASJC Scopus subject areas

Biochemistry
Biophysics
Molecular Biology

Cite this

Agnew, W., Moore, A. C., Levinson, S. R., & Raftery, M. A. (1980). Identification of a large molecular weight peptide associated with a tetrodotoxin binding protein from the electroplax of Electrophorus electricus. Biochemical and Biophysical Research Communications, 92(3), 860-866. https://doi.org/10.1016/0006-291X(80)90782-2

Identification of a large molecular weight peptide associated with a tetrodotoxin binding protein from the electroplax of Electrophorus electricus. / Agnew, William; Moore, Anne C.; Levinson, Simon R.; Raftery, Michael A.

In: Biochemical and Biophysical Research Communications, Vol. 92, No. 3, 12.02.1980, p. 860-866.

Research output: Contribution to journal › Article

Agnew, W, Moore, AC, Levinson, SR & Raftery, MA 1980, 'Identification of a large molecular weight peptide associated with a tetrodotoxin binding protein from the electroplax of Electrophorus electricus', Biochemical and Biophysical Research Communications, vol. 92, no. 3, pp. 860-866. https://doi.org/10.1016/0006-291X(80)90782-2

Agnew W, Moore AC, Levinson SR, Raftery MA. Identification of a large molecular weight peptide associated with a tetrodotoxin binding protein from the electroplax of Electrophorus electricus. Biochemical and Biophysical Research Communications. 1980 Feb 12;92(3):860-866. https://doi.org/10.1016/0006-291X(80)90782-2

Agnew, William ; Moore, Anne C. ; Levinson, Simon R. ; Raftery, Michael A. / Identification of a large molecular weight peptide associated with a tetrodotoxin binding protein from the electroplax of Electrophorus electricus. In: Biochemical and Biophysical Research Communications. 1980 ; Vol. 92, No. 3. pp. 860-866.

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10.1016/0006-291X(80)90782-2