We have previously described the purification of a tetrodotoxin binding protein from the electroplax of Electrophorus electricus. The preparation consisted of three peptides of Mr ∼ 46,000, 59,000 and ∼ 300,000 daltons. Further investigation has now shown that the large peptide of Mr ∼ 260,000 daltons is part of the tetrodotoxin binding component of the voltage-sensitive sodium channel.
|Original language||English (US)|
|Number of pages||7|
|Journal||Biochemical and Biophysical Research Communications|
|State||Published - Feb 12 1980|
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology