Identification of a large molecular weight peptide associated with a tetrodotoxin binding protein from the electroplax of Electrophorus electricus

William S. Agnew, Anne C. Moore, Simon R. Levinson, Michael A. Raftery

Research output: Contribution to journalArticlepeer-review

Abstract

We have previously described the purification of a tetrodotoxin binding protein from the electroplax of Electrophorus electricus. The preparation consisted of three peptides of Mr ∼ 46,000, 59,000 and ∼ 300,000 daltons. Further investigation has now shown that the large peptide of Mr ∼ 260,000 daltons is part of the tetrodotoxin binding component of the voltage-sensitive sodium channel.

Original languageEnglish (US)
Pages (from-to)860-866
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume92
Issue number3
DOIs
StatePublished - Feb 12 1980
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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