Abstract
We have identified a sequence in the TCR β2 locus that is homologous to the κB site in the Ig κ light chain enhancer. This element, TCRβ-B, is located in the vicinity of previously identified T cell-specific DNase1 hypersensitive sites. Transfection analysis shows that a 60-bp fragment encompassing this site is preferentially active in T cells stimulated with phorbol esters or the HTLV-1 tax gene product compared with a B cell line that constitutively expresses NF-κB. Our results provide the first evidence for transcriptional regulatory sequences residing within the Jβ2-Cβ2 intron and suggest the possible involvement of these sequences in modulation of TCRβ gene expression upon cellular activation.
Original language | English (US) |
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Pages (from-to) | 1737-1743 |
Number of pages | 7 |
Journal | Journal of Experimental Medicine |
Volume | 170 |
Issue number | 5 |
State | Published - 1989 |
Externally published | Yes |
ASJC Scopus subject areas
- Immunology