Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array

Rosalind A. Eeles, Ali Amin Al Olama, Sara Benlloch, Edward J. Saunders, Daniel A. Leongamornlert, Malgorzata Tymrakiewicz, Maya Ghoussaini, Craig Luccarini, Joe Dennis, Sarah Jugurnauth-Little, Tokhir Dadaev, David E. Neal, Freddie C. Hamdy, Jenny L. Donovan, Ken Muir, Graham G. Giles, Gianluca Severi, Fredrik Wiklund, Henrik Gronberg, Christopher A. Haiman & 124 others Fredrick Schumacher, Brian E. Henderson, Loic Le Marchand, Sara Lindstrom, Peter Kraft, David J. Hunter, Susan Gapstur, Stephen J. Chanock, Sonja I. Berndt, Demetrius Albanes, Gerald Andriole, Johanna Schleutker, Maren Weischer, Federico Canzian, Elio Riboli, Tim J. Key, Ruth C. Travis, Daniele Campa, Sue A. Ingles, Esther M. John, Richard B. Hayes, Paul D P Pharoah, Nora Pashayan, Kay Tee Khaw, Janet L. Stanford, Elaine A. Ostrander, Lisa B. Signorello, Stephen N. Thibodeau, Dan Schaid, Christiane Maier, Walther Vogel, Adam S. Kibel, Cezary Cybulski, Jan Lubinski, Lisa Cannon-Albright, Hermann Brenner, Jong Y. Park, Radka Kaneva, Jyotsna Batra, Amanda B. Spurdle, Judith A. Clements, Manuel R. Teixeira, Ed Dicks, Andrew Lee, Alison M. Dunning, Caroline Baynes, Don Conroy, Melanie J. Maranian, Shahana Ahmed, Koveela Govindasami, Michelle Guy, Rosemary A. Wilkinson, Emma J. Sawyer, Angela Morgan, David P. Dearnaley, Alan Horwich, Robert A. Huddart, Vincent S. Khoo, Christopher C. Parker, Nicholas J. Van As, Christopher J. Woodhouse, Alan Thompson, Tim Dudderidge, Chris Ogden, Colin S. Cooper, Artitaya Lophatananon, Angela Cox, Melissa C. Southey, John L. Hopper, Dallas R. English, Markus Aly, Jan Adolfsson, Jiangfeng Xu, Siqun L. Zheng, Meredith Yeager, Rudolf Kaaks, W. Ryan Diver, Mia M. Gaudet, Mariana C. Stern, Roman Corral, Amit D. Joshi, Ahva Shahabi, Tiina Wahlfors, Teuvo L J Tammela, Anssi Auvinen, Jarmo Virtamo, Peter Klarskov, Børge G. Nordestgaard, M. Andreas Røder, Sune F. Nielsen, Stig E. Bojesen, Afshan Siddiq, Liesel M. Fitzgerald, Suzanne Kolb, Erika M. Kwon, Danielle M. Karyadi, William J. Blot, Wei Zheng, Qiuyin Cai, Shannon K. McDonnell, Antje E. Rinckleb, Bettina Drake, Graham Colditz, Dominika Wokolorczyk, Robert A. Stephenson, Craig Teerlink, Heiko Muller, Dietrich Rothenbacher, Thomas A. Sellers, Hui Yi Lin, Chavdar Slavov, Vanio Mitev, Felicity Lose, Srilakshmi Srinivasan, Sofia Maia, Paula Paulo, Ethan Lange, Kathleen A. Cooney, Antonis C. Antoniou, Daniel Vincent, François Bacot, Daniel C. Tessier, Zsofia Kote-Jarai, Douglas F. Easton

Research output: Contribution to journalArticle

Abstract

Prostate cancer is the most frequently diagnosed cancer in males in developed countries. To identify common prostate cancer susceptibility alleles, we genotyped 211,155 SNPs on a custom Illumina array (iCOGS) in blood DNA from 25,074 prostate cancer cases and 24,272 controls from the international PRACTICAL Consortium. Twenty-three new prostate cancer susceptibility loci were identified at genome-wide significance (P <5 × 10 -8). More than 70 prostate cancer susceptibility loci, explaining ∼30% of the familial risk for this disease, have now been identified. On the basis of combined risks conferred by the new and previously known risk loci, the top 1% of the risk distribution has a 4.7-fold higher risk than the average of the population being profiled. These results will facilitate population risk stratification for clinical studies.

Original languageEnglish (US)
Pages (from-to)385-391
Number of pages7
JournalNature Genetics
Volume45
Issue number4
DOIs
StatePublished - Apr 2013
Externally publishedYes

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Prostatic Neoplasms
Developed Countries
Population
Single Nucleotide Polymorphism
Alleles
Genome
DNA
Neoplasms

ASJC Scopus subject areas

  • Genetics

Cite this

Eeles, R. A., Olama, A. A. A., Benlloch, S., Saunders, E. J., Leongamornlert, D. A., Tymrakiewicz, M., ... Easton, D. F. (2013). Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. Nature Genetics, 45(4), 385-391. https://doi.org/10.1038/ng.2560

Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. / Eeles, Rosalind A.; Olama, Ali Amin Al; Benlloch, Sara; Saunders, Edward J.; Leongamornlert, Daniel A.; Tymrakiewicz, Malgorzata; Ghoussaini, Maya; Luccarini, Craig; Dennis, Joe; Jugurnauth-Little, Sarah; Dadaev, Tokhir; Neal, David E.; Hamdy, Freddie C.; Donovan, Jenny L.; Muir, Ken; Giles, Graham G.; Severi, Gianluca; Wiklund, Fredrik; Gronberg, Henrik; Haiman, Christopher A.; Schumacher, Fredrick; Henderson, Brian E.; Le Marchand, Loic; Lindstrom, Sara; Kraft, Peter; Hunter, David J.; Gapstur, Susan; Chanock, Stephen J.; Berndt, Sonja I.; Albanes, Demetrius; Andriole, Gerald; Schleutker, Johanna; Weischer, Maren; Canzian, Federico; Riboli, Elio; Key, Tim J.; Travis, Ruth C.; Campa, Daniele; Ingles, Sue A.; John, Esther M.; Hayes, Richard B.; Pharoah, Paul D P; Pashayan, Nora; Khaw, Kay Tee; Stanford, Janet L.; Ostrander, Elaine A.; Signorello, Lisa B.; Thibodeau, Stephen N.; Schaid, Dan; Maier, Christiane; Vogel, Walther; Kibel, Adam S.; Cybulski, Cezary; Lubinski, Jan; Cannon-Albright, Lisa; Brenner, Hermann; Park, Jong Y.; Kaneva, Radka; Batra, Jyotsna; Spurdle, Amanda B.; Clements, Judith A.; Teixeira, Manuel R.; Dicks, Ed; Lee, Andrew; Dunning, Alison M.; Baynes, Caroline; Conroy, Don; Maranian, Melanie J.; Ahmed, Shahana; Govindasami, Koveela; Guy, Michelle; Wilkinson, Rosemary A.; Sawyer, Emma J.; Morgan, Angela; Dearnaley, David P.; Horwich, Alan; Huddart, Robert A.; Khoo, Vincent S.; Parker, Christopher C.; Van As, Nicholas J.; Woodhouse, Christopher J.; Thompson, Alan; Dudderidge, Tim; Ogden, Chris; Cooper, Colin S.; Lophatananon, Artitaya; Cox, Angela; Southey, Melissa C.; Hopper, John L.; English, Dallas R.; Aly, Markus; Adolfsson, Jan; Xu, Jiangfeng; Zheng, Siqun L.; Yeager, Meredith; Kaaks, Rudolf; Diver, W. Ryan; Gaudet, Mia M.; Stern, Mariana C.; Corral, Roman; Joshi, Amit D.; Shahabi, Ahva; Wahlfors, Tiina; Tammela, Teuvo L J; Auvinen, Anssi; Virtamo, Jarmo; Klarskov, Peter; Nordestgaard, Børge G.; Røder, M. Andreas; Nielsen, Sune F.; Bojesen, Stig E.; Siddiq, Afshan; Fitzgerald, Liesel M.; Kolb, Suzanne; Kwon, Erika M.; Karyadi, Danielle M.; Blot, William J.; Zheng, Wei; Cai, Qiuyin; McDonnell, Shannon K.; Rinckleb, Antje E.; Drake, Bettina; Colditz, Graham; Wokolorczyk, Dominika; Stephenson, Robert A.; Teerlink, Craig; Muller, Heiko; Rothenbacher, Dietrich; Sellers, Thomas A.; Lin, Hui Yi; Slavov, Chavdar; Mitev, Vanio; Lose, Felicity; Srinivasan, Srilakshmi; Maia, Sofia; Paulo, Paula; Lange, Ethan; Cooney, Kathleen A.; Antoniou, Antonis C.; Vincent, Daniel; Bacot, François; Tessier, Daniel C.; Kote-Jarai, Zsofia; Easton, Douglas F.

In: Nature Genetics, Vol. 45, No. 4, 04.2013, p. 385-391.

Research output: Contribution to journalArticle

Eeles, RA, Olama, AAA, Benlloch, S, Saunders, EJ, Leongamornlert, DA, Tymrakiewicz, M, Ghoussaini, M, Luccarini, C, Dennis, J, Jugurnauth-Little, S, Dadaev, T, Neal, DE, Hamdy, FC, Donovan, JL, Muir, K, Giles, GG, Severi, G, Wiklund, F, Gronberg, H, Haiman, CA, Schumacher, F, Henderson, BE, Le Marchand, L, Lindstrom, S, Kraft, P, Hunter, DJ, Gapstur, S, Chanock, SJ, Berndt, SI, Albanes, D, Andriole, G, Schleutker, J, Weischer, M, Canzian, F, Riboli, E, Key, TJ, Travis, RC, Campa, D, Ingles, SA, John, EM, Hayes, RB, Pharoah, PDP, Pashayan, N, Khaw, KT, Stanford, JL, Ostrander, EA, Signorello, LB, Thibodeau, SN, Schaid, D, Maier, C, Vogel, W, Kibel, AS, Cybulski, C, Lubinski, J, Cannon-Albright, L, Brenner, H, Park, JY, Kaneva, R, Batra, J, Spurdle, AB, Clements, JA, Teixeira, MR, Dicks, E, Lee, A, Dunning, AM, Baynes, C, Conroy, D, Maranian, MJ, Ahmed, S, Govindasami, K, Guy, M, Wilkinson, RA, Sawyer, EJ, Morgan, A, Dearnaley, DP, Horwich, A, Huddart, RA, Khoo, VS, Parker, CC, Van As, NJ, Woodhouse, CJ, Thompson, A, Dudderidge, T, Ogden, C, Cooper, CS, Lophatananon, A, Cox, A, Southey, MC, Hopper, JL, English, DR, Aly, M, Adolfsson, J, Xu, J, Zheng, SL, Yeager, M, Kaaks, R, Diver, WR, Gaudet, MM, Stern, MC, Corral, R, Joshi, AD, Shahabi, A, Wahlfors, T, Tammela, TLJ, Auvinen, A, Virtamo, J, Klarskov, P, Nordestgaard, BG, Røder, MA, Nielsen, SF, Bojesen, SE, Siddiq, A, Fitzgerald, LM, Kolb, S, Kwon, EM, Karyadi, DM, Blot, WJ, Zheng, W, Cai, Q, McDonnell, SK, Rinckleb, AE, Drake, B, Colditz, G, Wokolorczyk, D, Stephenson, RA, Teerlink, C, Muller, H, Rothenbacher, D, Sellers, TA, Lin, HY, Slavov, C, Mitev, V, Lose, F, Srinivasan, S, Maia, S, Paulo, P, Lange, E, Cooney, KA, Antoniou, AC, Vincent, D, Bacot, F, Tessier, DC, Kote-Jarai, Z & Easton, DF 2013, 'Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array', Nature Genetics, vol. 45, no. 4, pp. 385-391. https://doi.org/10.1038/ng.2560
Eeles RA, Olama AAA, Benlloch S, Saunders EJ, Leongamornlert DA, Tymrakiewicz M et al. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. Nature Genetics. 2013 Apr;45(4):385-391. https://doi.org/10.1038/ng.2560
Eeles, Rosalind A. ; Olama, Ali Amin Al ; Benlloch, Sara ; Saunders, Edward J. ; Leongamornlert, Daniel A. ; Tymrakiewicz, Malgorzata ; Ghoussaini, Maya ; Luccarini, Craig ; Dennis, Joe ; Jugurnauth-Little, Sarah ; Dadaev, Tokhir ; Neal, David E. ; Hamdy, Freddie C. ; Donovan, Jenny L. ; Muir, Ken ; Giles, Graham G. ; Severi, Gianluca ; Wiklund, Fredrik ; Gronberg, Henrik ; Haiman, Christopher A. ; Schumacher, Fredrick ; Henderson, Brian E. ; Le Marchand, Loic ; Lindstrom, Sara ; Kraft, Peter ; Hunter, David J. ; Gapstur, Susan ; Chanock, Stephen J. ; Berndt, Sonja I. ; Albanes, Demetrius ; Andriole, Gerald ; Schleutker, Johanna ; Weischer, Maren ; Canzian, Federico ; Riboli, Elio ; Key, Tim J. ; Travis, Ruth C. ; Campa, Daniele ; Ingles, Sue A. ; John, Esther M. ; Hayes, Richard B. ; Pharoah, Paul D P ; Pashayan, Nora ; Khaw, Kay Tee ; Stanford, Janet L. ; Ostrander, Elaine A. ; Signorello, Lisa B. ; Thibodeau, Stephen N. ; Schaid, Dan ; Maier, Christiane ; Vogel, Walther ; Kibel, Adam S. ; Cybulski, Cezary ; Lubinski, Jan ; Cannon-Albright, Lisa ; Brenner, Hermann ; Park, Jong Y. ; Kaneva, Radka ; Batra, Jyotsna ; Spurdle, Amanda B. ; Clements, Judith A. ; Teixeira, Manuel R. ; Dicks, Ed ; Lee, Andrew ; Dunning, Alison M. ; Baynes, Caroline ; Conroy, Don ; Maranian, Melanie J. ; Ahmed, Shahana ; Govindasami, Koveela ; Guy, Michelle ; Wilkinson, Rosemary A. ; Sawyer, Emma J. ; Morgan, Angela ; Dearnaley, David P. ; Horwich, Alan ; Huddart, Robert A. ; Khoo, Vincent S. ; Parker, Christopher C. ; Van As, Nicholas J. ; Woodhouse, Christopher J. ; Thompson, Alan ; Dudderidge, Tim ; Ogden, Chris ; Cooper, Colin S. ; Lophatananon, Artitaya ; Cox, Angela ; Southey, Melissa C. ; Hopper, John L. ; English, Dallas R. ; Aly, Markus ; Adolfsson, Jan ; Xu, Jiangfeng ; Zheng, Siqun L. ; Yeager, Meredith ; Kaaks, Rudolf ; Diver, W. Ryan ; Gaudet, Mia M. ; Stern, Mariana C. ; Corral, Roman ; Joshi, Amit D. ; Shahabi, Ahva ; Wahlfors, Tiina ; Tammela, Teuvo L J ; Auvinen, Anssi ; Virtamo, Jarmo ; Klarskov, Peter ; Nordestgaard, Børge G. ; Røder, M. Andreas ; Nielsen, Sune F. ; Bojesen, Stig E. ; Siddiq, Afshan ; Fitzgerald, Liesel M. ; Kolb, Suzanne ; Kwon, Erika M. ; Karyadi, Danielle M. ; Blot, William J. ; Zheng, Wei ; Cai, Qiuyin ; McDonnell, Shannon K. ; Rinckleb, Antje E. ; Drake, Bettina ; Colditz, Graham ; Wokolorczyk, Dominika ; Stephenson, Robert A. ; Teerlink, Craig ; Muller, Heiko ; Rothenbacher, Dietrich ; Sellers, Thomas A. ; Lin, Hui Yi ; Slavov, Chavdar ; Mitev, Vanio ; Lose, Felicity ; Srinivasan, Srilakshmi ; Maia, Sofia ; Paulo, Paula ; Lange, Ethan ; Cooney, Kathleen A. ; Antoniou, Antonis C. ; Vincent, Daniel ; Bacot, François ; Tessier, Daniel C. ; Kote-Jarai, Zsofia ; Easton, Douglas F. / Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. In: Nature Genetics. 2013 ; Vol. 45, No. 4. pp. 385-391.
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abstract = "Prostate cancer is the most frequently diagnosed cancer in males in developed countries. To identify common prostate cancer susceptibility alleles, we genotyped 211,155 SNPs on a custom Illumina array (iCOGS) in blood DNA from 25,074 prostate cancer cases and 24,272 controls from the international PRACTICAL Consortium. Twenty-three new prostate cancer susceptibility loci were identified at genome-wide significance (P <5 × 10 -8). More than 70 prostate cancer susceptibility loci, explaining ∼30{\%} of the familial risk for this disease, have now been identified. On the basis of combined risks conferred by the new and previously known risk loci, the top 1{\%} of the risk distribution has a 4.7-fold higher risk than the average of the population being profiled. These results will facilitate population risk stratification for clinical studies.",
author = "Eeles, {Rosalind A.} and Olama, {Ali Amin Al} and Sara Benlloch and Saunders, {Edward J.} and Leongamornlert, {Daniel A.} and Malgorzata Tymrakiewicz and Maya Ghoussaini and Craig Luccarini and Joe Dennis and Sarah Jugurnauth-Little and Tokhir Dadaev and Neal, {David E.} and Hamdy, {Freddie C.} and Donovan, {Jenny L.} and Ken Muir and Giles, {Graham G.} and Gianluca Severi and Fredrik Wiklund and Henrik Gronberg and Haiman, {Christopher A.} and Fredrick Schumacher and Henderson, {Brian E.} and {Le Marchand}, Loic and Sara Lindstrom and Peter Kraft and Hunter, {David J.} and Susan Gapstur and Chanock, {Stephen J.} and Berndt, {Sonja I.} and Demetrius Albanes and Gerald Andriole and Johanna Schleutker and Maren Weischer and Federico Canzian and Elio Riboli and Key, {Tim J.} and Travis, {Ruth C.} and Daniele Campa and Ingles, {Sue A.} and John, {Esther M.} and Hayes, {Richard B.} and Pharoah, {Paul D P} and Nora Pashayan and Khaw, {Kay Tee} and Stanford, {Janet L.} and Ostrander, {Elaine A.} and Signorello, {Lisa B.} and Thibodeau, {Stephen N.} and Dan Schaid and Christiane Maier and Walther Vogel and Kibel, {Adam S.} and Cezary Cybulski and Jan Lubinski and Lisa Cannon-Albright and Hermann Brenner and Park, {Jong Y.} and Radka Kaneva and Jyotsna Batra and Spurdle, {Amanda B.} and Clements, {Judith A.} and Teixeira, {Manuel R.} and Ed Dicks and Andrew Lee and Dunning, {Alison M.} and Caroline Baynes and Don Conroy and Maranian, {Melanie J.} and Shahana Ahmed and Koveela Govindasami and Michelle Guy and Wilkinson, {Rosemary A.} and Sawyer, {Emma J.} and Angela Morgan and Dearnaley, {David P.} and Alan Horwich and Huddart, {Robert A.} and Khoo, {Vincent S.} and Parker, {Christopher C.} and {Van As}, {Nicholas J.} and Woodhouse, {Christopher J.} and Alan Thompson and Tim Dudderidge and Chris Ogden and Cooper, {Colin S.} and Artitaya Lophatananon and Angela Cox and Southey, {Melissa C.} and Hopper, {John L.} and English, {Dallas R.} and Markus Aly and Jan Adolfsson and Jiangfeng Xu and Zheng, {Siqun L.} and Meredith Yeager and Rudolf Kaaks and Diver, {W. Ryan} and Gaudet, {Mia M.} and Stern, {Mariana C.} and Roman Corral and Joshi, {Amit D.} and Ahva Shahabi and Tiina Wahlfors and Tammela, {Teuvo L J} and Anssi Auvinen and Jarmo Virtamo and Peter Klarskov and Nordestgaard, {B{\o}rge G.} and R{\o}der, {M. Andreas} and Nielsen, {Sune F.} and Bojesen, {Stig E.} and Afshan Siddiq and Fitzgerald, {Liesel M.} and Suzanne Kolb and Kwon, {Erika M.} and Karyadi, {Danielle M.} and Blot, {William J.} and Wei Zheng and Qiuyin Cai and McDonnell, {Shannon K.} and Rinckleb, {Antje E.} and Bettina Drake and Graham Colditz and Dominika Wokolorczyk and Stephenson, {Robert A.} and Craig Teerlink and Heiko Muller and Dietrich Rothenbacher and Sellers, {Thomas A.} and Lin, {Hui Yi} and Chavdar Slavov and Vanio Mitev and Felicity Lose and Srilakshmi Srinivasan and Sofia Maia and Paula Paulo and Ethan Lange and Cooney, {Kathleen A.} and Antoniou, {Antonis C.} and Daniel Vincent and Fran{\cc}ois Bacot and Tessier, {Daniel C.} and Zsofia Kote-Jarai and Easton, {Douglas F.}",
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AU - Eeles, Rosalind A.

AU - Olama, Ali Amin Al

AU - Benlloch, Sara

AU - Saunders, Edward J.

AU - Leongamornlert, Daniel A.

AU - Tymrakiewicz, Malgorzata

AU - Ghoussaini, Maya

AU - Luccarini, Craig

AU - Dennis, Joe

AU - Jugurnauth-Little, Sarah

AU - Dadaev, Tokhir

AU - Neal, David E.

AU - Hamdy, Freddie C.

AU - Donovan, Jenny L.

AU - Muir, Ken

AU - Giles, Graham G.

AU - Severi, Gianluca

AU - Wiklund, Fredrik

AU - Gronberg, Henrik

AU - Haiman, Christopher A.

AU - Schumacher, Fredrick

AU - Henderson, Brian E.

AU - Le Marchand, Loic

AU - Lindstrom, Sara

AU - Kraft, Peter

AU - Hunter, David J.

AU - Gapstur, Susan

AU - Chanock, Stephen J.

AU - Berndt, Sonja I.

AU - Albanes, Demetrius

AU - Andriole, Gerald

AU - Schleutker, Johanna

AU - Weischer, Maren

AU - Canzian, Federico

AU - Riboli, Elio

AU - Key, Tim J.

AU - Travis, Ruth C.

AU - Campa, Daniele

AU - Ingles, Sue A.

AU - John, Esther M.

AU - Hayes, Richard B.

AU - Pharoah, Paul D P

AU - Pashayan, Nora

AU - Khaw, Kay Tee

AU - Stanford, Janet L.

AU - Ostrander, Elaine A.

AU - Signorello, Lisa B.

AU - Thibodeau, Stephen N.

AU - Schaid, Dan

AU - Maier, Christiane

AU - Vogel, Walther

AU - Kibel, Adam S.

AU - Cybulski, Cezary

AU - Lubinski, Jan

AU - Cannon-Albright, Lisa

AU - Brenner, Hermann

AU - Park, Jong Y.

AU - Kaneva, Radka

AU - Batra, Jyotsna

AU - Spurdle, Amanda B.

AU - Clements, Judith A.

AU - Teixeira, Manuel R.

AU - Dicks, Ed

AU - Lee, Andrew

AU - Dunning, Alison M.

AU - Baynes, Caroline

AU - Conroy, Don

AU - Maranian, Melanie J.

AU - Ahmed, Shahana

AU - Govindasami, Koveela

AU - Guy, Michelle

AU - Wilkinson, Rosemary A.

AU - Sawyer, Emma J.

AU - Morgan, Angela

AU - Dearnaley, David P.

AU - Horwich, Alan

AU - Huddart, Robert A.

AU - Khoo, Vincent S.

AU - Parker, Christopher C.

AU - Van As, Nicholas J.

AU - Woodhouse, Christopher J.

AU - Thompson, Alan

AU - Dudderidge, Tim

AU - Ogden, Chris

AU - Cooper, Colin S.

AU - Lophatananon, Artitaya

AU - Cox, Angela

AU - Southey, Melissa C.

AU - Hopper, John L.

AU - English, Dallas R.

AU - Aly, Markus

AU - Adolfsson, Jan

AU - Xu, Jiangfeng

AU - Zheng, Siqun L.

AU - Yeager, Meredith

AU - Kaaks, Rudolf

AU - Diver, W. Ryan

AU - Gaudet, Mia M.

AU - Stern, Mariana C.

AU - Corral, Roman

AU - Joshi, Amit D.

AU - Shahabi, Ahva

AU - Wahlfors, Tiina

AU - Tammela, Teuvo L J

AU - Auvinen, Anssi

AU - Virtamo, Jarmo

AU - Klarskov, Peter

AU - Nordestgaard, Børge G.

AU - Røder, M. Andreas

AU - Nielsen, Sune F.

AU - Bojesen, Stig E.

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AU - Fitzgerald, Liesel M.

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AU - Kwon, Erika M.

AU - Karyadi, Danielle M.

AU - Blot, William J.

AU - Zheng, Wei

AU - Cai, Qiuyin

AU - McDonnell, Shannon K.

AU - Rinckleb, Antje E.

AU - Drake, Bettina

AU - Colditz, Graham

AU - Wokolorczyk, Dominika

AU - Stephenson, Robert A.

AU - Teerlink, Craig

AU - Muller, Heiko

AU - Rothenbacher, Dietrich

AU - Sellers, Thomas A.

AU - Lin, Hui Yi

AU - Slavov, Chavdar

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AU - Paulo, Paula

AU - Lange, Ethan

AU - Cooney, Kathleen A.

AU - Antoniou, Antonis C.

AU - Vincent, Daniel

AU - Bacot, François

AU - Tessier, Daniel C.

AU - Kote-Jarai, Zsofia

AU - Easton, Douglas F.

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AB - Prostate cancer is the most frequently diagnosed cancer in males in developed countries. To identify common prostate cancer susceptibility alleles, we genotyped 211,155 SNPs on a custom Illumina array (iCOGS) in blood DNA from 25,074 prostate cancer cases and 24,272 controls from the international PRACTICAL Consortium. Twenty-three new prostate cancer susceptibility loci were identified at genome-wide significance (P <5 × 10 -8). More than 70 prostate cancer susceptibility loci, explaining ∼30% of the familial risk for this disease, have now been identified. On the basis of combined risks conferred by the new and previously known risk loci, the top 1% of the risk distribution has a 4.7-fold higher risk than the average of the population being profiled. These results will facilitate population risk stratification for clinical studies.

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