Identification in rats of N-nitrosonipecotic acid as a major urinary metabolite of the areca-nut alkaloid-derived nitrosamines, N-nitrosoguvacoline and N-nitrosoguvacine

H. Ohshima, M. Friesen, H. Bartsch

Research output: Contribution to journalArticle

Abstract

N-Nitrosamines derived from areca-nut alkaloids have been implicated in cancer of the oral cavity and esophagus caused by betel quid chewing in India and other Asian countries. A major urinary metabolite of N-nitrosoguvacoline and N-nitrosoguvacine, both present in saliva of betel quid chewers of ppb levels, was isolated from rat urine and identified as N-nitrosonipecotic acid by comparison with the authentic compound. When a dose of 50 or 500 μg/rat of either compound was administered orally to BDIV rats, 66-85% of the dose was excreted in the urine as N-nitrosonipecotic acid and 2-8% as N-nitrosoguvacine. These N-nitrosamino acids could be analysed in the urine of betel quid chewers as a marker of exposure to areca-nut specific nitrosamines.

Original languageEnglish (US)
Pages (from-to)211-216
Number of pages6
JournalCancer Letters
Volume44
Issue number3
DOIs
StatePublished - Mar 1989

Keywords

  • N-nitrosoguvacine
  • N-nitrosoguvacoline
  • N-nitrosonipecotic acid
  • areca-nut derived nitrosamines
  • urinary metabolites

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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