TY - JOUR
T1 - Identification and selection of cases and controls in the pneumonia etiology research for child health project
AU - Deloria-Knoll, Maria
AU - Feikin, Daniel R.
AU - Scott, J. Anthony G.
AU - O'Brien, Katherine L.
AU - Deluca, Andrea N.
AU - Driscoll, Amanda J.
AU - Levine, Orin S.
N1 - Funding Information:
Supplement sponsorship. This article was published as part of a supplement entitled ‘‘Pneumonia Etiology Research for Child Health,’’ sponsored by a grant from The Bill & Melinda Gates Foundation to the PERCH Project of Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland. Potential conflicts of interest. All authors: No reported conflicts.
Funding Information:
Financial support. This work was supported by grant 48968 from The Bill & Melinda Gates Foundation to the International Vaccine Access Center, Department of International Health, Johns Hopkins Bloomberg School of Public Health. J. A. G. S. is supported by a clinical fellowship from The Wellcome Trust of Great Britain (081835).
PY - 2012/4/1
Y1 - 2012/4/1
N2 - Methods for the identification and selection of patients (cases) with severe or very severe pneumonia and controls for the Pneumonia Etiology Research for Child Health (PERCH) project were needed. Issues considered include eligibility criteria and sampling strategies, whether to enroll hospital or community controls, whether to exclude controls with upper respiratory tract infection (URTI) or nonsevere pneumonia, and matching criteria, among others. PERCH ultimately decided to enroll community controls and an additional human immunodeficiency virus (HIV)-infected control group at high HIV-prevalence sites matched on age and enrollment date of cases; controls with symptoms of URTI or nonsevere pneumonia will not be excluded. Systematic sampling of cases (when necessary) and random sampling of controls will be implemented. For each issue, we present the options that were considered, the advantages and disadvantages of each, the rationale for the methods selected for PERCH, and remaining implications and limitations.
AB - Methods for the identification and selection of patients (cases) with severe or very severe pneumonia and controls for the Pneumonia Etiology Research for Child Health (PERCH) project were needed. Issues considered include eligibility criteria and sampling strategies, whether to enroll hospital or community controls, whether to exclude controls with upper respiratory tract infection (URTI) or nonsevere pneumonia, and matching criteria, among others. PERCH ultimately decided to enroll community controls and an additional human immunodeficiency virus (HIV)-infected control group at high HIV-prevalence sites matched on age and enrollment date of cases; controls with symptoms of URTI or nonsevere pneumonia will not be excluded. Systematic sampling of cases (when necessary) and random sampling of controls will be implemented. For each issue, we present the options that were considered, the advantages and disadvantages of each, the rationale for the methods selected for PERCH, and remaining implications and limitations.
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U2 - 10.1093/cid/cir1066
DO - 10.1093/cid/cir1066
M3 - Article
C2 - 22403225
AN - SCOPUS:84858121227
SN - 1058-4838
VL - 54
SP - S117-S123
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
IS - SUPPL. 2
ER -