TY - JOUR
T1 - Identification and occurrence of two new N-nitrosamino acids in tobacco products
T2 - 3-(N-nitroso-N-methylamino) propionic acid and 4-(N-nitroso-N-methylamino) butyric acid
AU - Ohshima, Hiroshi
AU - Nair, Jagadeesan
AU - Bourgade, Marie Christine
AU - Friesen, Marlin
AU - Garren, Liliane
AU - Bartsch, Helmut
N1 - Funding Information:
are also grateful to Mrs E. Heseltine and Mrs M.B. D’Arcy for editorial and secretarial assistance,r espectively. One of the authors (JN) is a recipient of a Research and Training Fellowship awarded by the International Agency for Research on Cancer.
PY - 1985/3
Y1 - 1985/3
N2 - Two new N-nitrosamino acids, 3-(N-nitroso-N-methylamino)propionic acid (CAS: 10478-42-9) and 4-(N-nitroso-N-methylamino)butyric acid (CAS: 61445-55-4) were isolated and identified for the first time in various types of tobacco, including snuff, chewing and pipe tobacco, cigars and cigarettes. Their levels ranged from 0.15 to 7.4 and 0 to 2.2 mg/kg of dry weight tobacco, respectively. For comparison, amounts of other N-nitrosamino acids like N-nitrosoproline (NPRO) and tobacco-specific-nitrosamines (TSNA) were determined in the same samples. The levels of N-nitrosamino acids were highly correlated with the levels of TSNA.
AB - Two new N-nitrosamino acids, 3-(N-nitroso-N-methylamino)propionic acid (CAS: 10478-42-9) and 4-(N-nitroso-N-methylamino)butyric acid (CAS: 61445-55-4) were isolated and identified for the first time in various types of tobacco, including snuff, chewing and pipe tobacco, cigars and cigarettes. Their levels ranged from 0.15 to 7.4 and 0 to 2.2 mg/kg of dry weight tobacco, respectively. For comparison, amounts of other N-nitrosamino acids like N-nitrosoproline (NPRO) and tobacco-specific-nitrosamines (TSNA) were determined in the same samples. The levels of N-nitrosamino acids were highly correlated with the levels of TSNA.
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U2 - 10.1016/0304-3835(85)90021-7
DO - 10.1016/0304-3835(85)90021-7
M3 - Article
C2 - 3978605
AN - SCOPUS:84886642061
SN - 0304-3835
VL - 26
SP - 153
EP - 162
JO - Cancer Letters
JF - Cancer Letters
IS - 2
ER -