Identification and occurrence of two new N-nitrosamino acids in tobacco products: 3-(N-nitroso-N-methylamino) propionic acid and 4-(N-nitroso-N-methylamino) butyric acid

Hiroshi Ohshima, Jagadeesan Nair, Marie Christine Bourgade, Marlin Friesen, Liliane Garren, Helmut Bartsch

Research output: Contribution to journalArticle

Abstract

Two new N-nitrosamino acids, 3-(N-nitroso-N-methylamino)propionic acid (CAS: 10478-42-9) and 4-(N-nitroso-N-methylamino)butyric acid (CAS: 61445-55-4) were isolated and identified for the first time in various types of tobacco, including snuff, chewing and pipe tobacco, cigars and cigarettes. Their levels ranged from 0.15 to 7.4 and 0 to 2.2 mg/kg of dry weight tobacco, respectively. For comparison, amounts of other N-nitrosamino acids like N-nitrosoproline (NPRO) and tobacco-specific-nitrosamines (TSNA) were determined in the same samples. The levels of N-nitrosamino acids were highly correlated with the levels of TSNA.

Original languageEnglish (US)
Pages (from-to)153-162
Number of pages10
JournalCancer Letters
Volume26
Issue number2
DOIs
StatePublished - 1985
Externally publishedYes

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3-(N-nitroso-N-methylamino)propionic acid
4-(N-nitroso-N-methylamino)butyric acid
Tobacco Products
Tobacco
Smokeless Tobacco
Nitrosamines
Acids
Weights and Measures

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

Cite this

Identification and occurrence of two new N-nitrosamino acids in tobacco products : 3-(N-nitroso-N-methylamino) propionic acid and 4-(N-nitroso-N-methylamino) butyric acid. / Ohshima, Hiroshi; Nair, Jagadeesan; Bourgade, Marie Christine; Friesen, Marlin; Garren, Liliane; Bartsch, Helmut.

In: Cancer Letters, Vol. 26, No. 2, 1985, p. 153-162.

Research output: Contribution to journalArticle

Ohshima, Hiroshi ; Nair, Jagadeesan ; Bourgade, Marie Christine ; Friesen, Marlin ; Garren, Liliane ; Bartsch, Helmut. / Identification and occurrence of two new N-nitrosamino acids in tobacco products : 3-(N-nitroso-N-methylamino) propionic acid and 4-(N-nitroso-N-methylamino) butyric acid. In: Cancer Letters. 1985 ; Vol. 26, No. 2. pp. 153-162.
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AU - Friesen, Marlin

AU - Garren, Liliane

AU - Bartsch, Helmut

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