Identification and analysis of precursors to invasive pancreatic cancer

Hanno Matthaei, Marco Dal Molin, Anirban Maitra

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Precursor lesions of pancreatic cancer have been recognized about a century ago. The development of a consistent reproducible nomenclature and classification system for these lesions has been a major advance in the study of these noninvasive precursors. Pancreatic intraepithelial neoplasia (PanIN) as microscopic precursor lesions can be distinguished from mucinous cystic neoplasms (MCNs) and intraductal papillary mucinous neoplasms (IPMN) that are cystic and can often be recognized on imaging. Since precursor lesions harbor the unique chance to treat a patient before a fatal pancreatic cancer can arise a molecular characterization is essential to understand the biology and tofind diagnostic and therapeutic targets tofight this disease of near uniform lethality. In order to study precursor lesions on a molecular level a meticulous isolation of the neoplastic cells is inevitable. We present the salient histopathologic and molecular features of precursor lesions of pancreatic cancer as well as methods that have proved to be useful within experimental studies.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages1-12
Number of pages12
Volume980
ISBN (Print)9781627032865
DOIs
StatePublished - 2013
Externally publishedYes

Publication series

NameMethods in Molecular Biology
Volume980
ISSN (Print)10643745

Fingerprint

Pancreatic Neoplasms
Neoplasms
Cell Separation
Terminology
Therapeutics

Keywords

  • IPMN
  • MCN
  • Microdissection
  • PanIN
  • Precursor lesions

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Medicine(all)

Cite this

Matthaei, H., Dal Molin, M., & Maitra, A. (2013). Identification and analysis of precursors to invasive pancreatic cancer. In Methods in Molecular Biology (Vol. 980, pp. 1-12). (Methods in Molecular Biology; Vol. 980). Humana Press Inc.. https://doi.org/10.1007/978-1-62703-287-2_1

Identification and analysis of precursors to invasive pancreatic cancer. / Matthaei, Hanno; Dal Molin, Marco; Maitra, Anirban.

Methods in Molecular Biology. Vol. 980 Humana Press Inc., 2013. p. 1-12 (Methods in Molecular Biology; Vol. 980).

Research output: Chapter in Book/Report/Conference proceedingChapter

Matthaei, H, Dal Molin, M & Maitra, A 2013, Identification and analysis of precursors to invasive pancreatic cancer. in Methods in Molecular Biology. vol. 980, Methods in Molecular Biology, vol. 980, Humana Press Inc., pp. 1-12. https://doi.org/10.1007/978-1-62703-287-2_1
Matthaei H, Dal Molin M, Maitra A. Identification and analysis of precursors to invasive pancreatic cancer. In Methods in Molecular Biology. Vol. 980. Humana Press Inc. 2013. p. 1-12. (Methods in Molecular Biology). https://doi.org/10.1007/978-1-62703-287-2_1
Matthaei, Hanno ; Dal Molin, Marco ; Maitra, Anirban. / Identification and analysis of precursors to invasive pancreatic cancer. Methods in Molecular Biology. Vol. 980 Humana Press Inc., 2013. pp. 1-12 (Methods in Molecular Biology).
@inbook{6e6e2c163deb48e6bdd810d63f68a789,
title = "Identification and analysis of precursors to invasive pancreatic cancer",
abstract = "Precursor lesions of pancreatic cancer have been recognized about a century ago. The development of a consistent reproducible nomenclature and classification system for these lesions has been a major advance in the study of these noninvasive precursors. Pancreatic intraepithelial neoplasia (PanIN) as microscopic precursor lesions can be distinguished from mucinous cystic neoplasms (MCNs) and intraductal papillary mucinous neoplasms (IPMN) that are cystic and can often be recognized on imaging. Since precursor lesions harbor the unique chance to treat a patient before a fatal pancreatic cancer can arise a molecular characterization is essential to understand the biology and tofind diagnostic and therapeutic targets tofight this disease of near uniform lethality. In order to study precursor lesions on a molecular level a meticulous isolation of the neoplastic cells is inevitable. We present the salient histopathologic and molecular features of precursor lesions of pancreatic cancer as well as methods that have proved to be useful within experimental studies.",
keywords = "IPMN, MCN, Microdissection, PanIN, Precursor lesions",
author = "Hanno Matthaei and {Dal Molin}, Marco and Anirban Maitra",
year = "2013",
doi = "10.1007/978-1-62703-287-2_1",
language = "English (US)",
isbn = "9781627032865",
volume = "980",
series = "Methods in Molecular Biology",
publisher = "Humana Press Inc.",
pages = "1--12",
booktitle = "Methods in Molecular Biology",

}

TY - CHAP

T1 - Identification and analysis of precursors to invasive pancreatic cancer

AU - Matthaei, Hanno

AU - Dal Molin, Marco

AU - Maitra, Anirban

PY - 2013

Y1 - 2013

N2 - Precursor lesions of pancreatic cancer have been recognized about a century ago. The development of a consistent reproducible nomenclature and classification system for these lesions has been a major advance in the study of these noninvasive precursors. Pancreatic intraepithelial neoplasia (PanIN) as microscopic precursor lesions can be distinguished from mucinous cystic neoplasms (MCNs) and intraductal papillary mucinous neoplasms (IPMN) that are cystic and can often be recognized on imaging. Since precursor lesions harbor the unique chance to treat a patient before a fatal pancreatic cancer can arise a molecular characterization is essential to understand the biology and tofind diagnostic and therapeutic targets tofight this disease of near uniform lethality. In order to study precursor lesions on a molecular level a meticulous isolation of the neoplastic cells is inevitable. We present the salient histopathologic and molecular features of precursor lesions of pancreatic cancer as well as methods that have proved to be useful within experimental studies.

AB - Precursor lesions of pancreatic cancer have been recognized about a century ago. The development of a consistent reproducible nomenclature and classification system for these lesions has been a major advance in the study of these noninvasive precursors. Pancreatic intraepithelial neoplasia (PanIN) as microscopic precursor lesions can be distinguished from mucinous cystic neoplasms (MCNs) and intraductal papillary mucinous neoplasms (IPMN) that are cystic and can often be recognized on imaging. Since precursor lesions harbor the unique chance to treat a patient before a fatal pancreatic cancer can arise a molecular characterization is essential to understand the biology and tofind diagnostic and therapeutic targets tofight this disease of near uniform lethality. In order to study precursor lesions on a molecular level a meticulous isolation of the neoplastic cells is inevitable. We present the salient histopathologic and molecular features of precursor lesions of pancreatic cancer as well as methods that have proved to be useful within experimental studies.

KW - IPMN

KW - MCN

KW - Microdissection

KW - PanIN

KW - Precursor lesions

UR - http://www.scopus.com/inward/record.url?scp=84879558461&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84879558461&partnerID=8YFLogxK

U2 - 10.1007/978-1-62703-287-2_1

DO - 10.1007/978-1-62703-287-2_1

M3 - Chapter

C2 - 23359146

AN - SCOPUS:84879558461

SN - 9781627032865

VL - 980

T3 - Methods in Molecular Biology

SP - 1

EP - 12

BT - Methods in Molecular Biology

PB - Humana Press Inc.

ER -