TY - JOUR
T1 - Identification and analysis of plasticity-induced late-response genes
AU - Hong, Suk Jin
AU - Li, Huiwu
AU - Becker, Kevin G.
AU - Dawson, Valina L.
AU - Dawson, Ted M.
PY - 2004/2/17
Y1 - 2004/2/17
N2 - The excitatory neurotransmitter, glutamate, activates N-methyl-D-aspartate (NMDA) receptors to induce long-lasting synaptic changes through alterations in gene expression. It is believed that these long-lasting changes contribute to learning and memory, drug tolerance, and ischemic preconditioning. To identify NMDA-induced late-response genes, we used a powerful gene-identification method, differential analysis of primary cDNA library expression (DAzLE), and cDNA microarray from primary cortical neurons. We report here that a variety of genes, which we have named plasticity-induced genes (PLINGs), are up-regulated with differential expression patterns after NMDA receptor activation, indicating that there is a broad and dynamic range of long-lasting neuronal responses that occur through NMDA receptor activation. Our results provide a molecular dissection of the activity-dependent long-lasting neuronal responses induced by NMDA receptor activation.
AB - The excitatory neurotransmitter, glutamate, activates N-methyl-D-aspartate (NMDA) receptors to induce long-lasting synaptic changes through alterations in gene expression. It is believed that these long-lasting changes contribute to learning and memory, drug tolerance, and ischemic preconditioning. To identify NMDA-induced late-response genes, we used a powerful gene-identification method, differential analysis of primary cDNA library expression (DAzLE), and cDNA microarray from primary cortical neurons. We report here that a variety of genes, which we have named plasticity-induced genes (PLINGs), are up-regulated with differential expression patterns after NMDA receptor activation, indicating that there is a broad and dynamic range of long-lasting neuronal responses that occur through NMDA receptor activation. Our results provide a molecular dissection of the activity-dependent long-lasting neuronal responses induced by NMDA receptor activation.
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U2 - 10.1073/pnas.0305170101
DO - 10.1073/pnas.0305170101
M3 - Article
C2 - 14766980
AN - SCOPUS:1242296773
SN - 0027-8424
VL - 101
SP - 2145
EP - 2150
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 7
ER -