TY - JOUR
T1 - Ideal cardiovascular health and resting heart rate in the Multi-Ethnic Study of Atherosclerosis
AU - Osibogun, Olatokunbo
AU - Ogunmoroti, Oluseye
AU - Spatz, Erica S.
AU - Fashanu, Oluwaseun E.
AU - Michos, Erin D.
N1 - Funding Information:
The authors thank the other investigators, the staff, and the participants of the Multi-Ethnic Study of Atherosclerosis for their valuable contributions. A full list of participating MESA investigators and institutions can be found at http://www.mesa-nhlbi.org. This study was conducted under the guiding principles of the Declaration of Helsinki for the protection of human subjects. Institutional Review Boards of all participating MESA sites approved the study, and all participants signed informed consent. At the Johns Hopkins Field Center, the MESA Study was approved by the Johns Hopkins School of Medicine Office of Human Subjects Research Institutional Review Board; Principal Investigator: Dr. Wendy Post; approval number: NA_00030361/CR00015436; Title: Multi-Ethnic Study of Atherosclerosis (MESA). The Multi-Ethnic Study of Atherosclerosis is supported by contracts N01-HC-95159, N01-HC-95160, N01-HC-95161, N01-HC-95162, N01-HC-95163, N01-HC-95164, N01-HC-95165, N01-HC-95166, N01-HC-95167, N01-HC-95168, N01-HC-95169 and HHSN268201500003I from the National Heart, Lung, and Blood Institute (NHLBI) and by grants UL1-RR-024156 and UL1-RR-025005 from the National Center for Research Resources (NCRR). Dr. Michos is supported by the Blumenthal Scholars Fund for Preventive Cardiology Research. All funding sources have no role in the analysis and interpretation and in the writing of the manuscript. The MESA study participates in data sharing through the National Heart, Lung, Blood Institute (NHLBI) Biologic Specimen and Data Repository Coordinating Center (BioLINCC). Requests for access to the data can be made through their website: https://biolincc.nhlbi.nih.gov/studies/mesa/. OO (first author), OO (second author), and EM designed the study. OO and OO performed the statistical analyses and drafted the manuscript. OO, OO, ES, OF and EM provided critical revisions to the manuscript. OO (first author) and EM take full responsibility for the content. All authors have read and approved the final manuscript draft. The manuscript was approved by the MESA Publication Committee. The authors declare that they have no conflicts of interest.
Funding Information:
The Multi-Ethnic Study of Atherosclerosis is supported by contracts N01-HC-95159 , N01-HC-95160 , N01-HC-95161 , N01-HC-95162 , N01-HC-95163 , N01-HC-95164 , N01-HC-95165 , N01-HC-95166 , N01-HC-95167 , N01-HC-95168 , N01-HC-95169 and HHSN268201500003I from the National Heart, Lung, and Blood Institute (NHLBI) and by grants UL1-RR-024156 and UL1-RR-025005 from the National Center for Research Resources (NCRR). Dr. Michos is supported by the Blumenthal Scholars Fund for Preventive Cardiology Research . All funding sources have no role in the analysis and interpretation and in the writing of the manuscript.
Publisher Copyright:
© 2019 Elsevier Inc.
PY - 2020/1
Y1 - 2020/1
N2 - Elevated resting heart rate (RHR) is associated with an increased cardiovascular disease (CVD) risk, but little is known about its association with cardiovascular health (CVH), assessed by the Life's Simple 7 (LS7) metrics. We explored whether ideal CVH was associated with RHR in a cohort free from clinical CVD. We conducted a cross-sectional analysis of baseline data (2000−2002) of 6457 Multi-Ethnic Study of Atherosclerosis participants in 2018. Each LS7 metric (smoking, physical activity, diet, body mass index, blood pressure, cholesterol and glucose) was scored 0–2. Total score ranged from 0 to 14. Scores of 0–8 indicate inadequate, 9–10 average, and 11–14 optimal CVH. RHR was categorized as <60, 60–69, 70–79 and ≥80 bpm. We used multinomial logistic regression to determine associations between CVH score and RHR, adjusting for age, sex, race/ethnicity, education, income, health insurance, and atrioventricular nodal blockers. Mean age of participants (standard deviation) was 62 (10) years; 53% were women; 47% had inadequate CVH, 33% average, and 20% optimal. Favorable CVH was associated with lower odds of having higher RHR. Compared to RHR <60 bpm, participants with optimal CVH had adjusted odds ratio (95% CI) of 0.55 (0.46–0.64) for RHR of 60-69 bpm, 0.34 (0.28–0.43) for 70–79 bpm, and 0.14 (0.09–0.22) for ≥80 bpm. A similar pattern was observed in the stratified analysis by sex, race/ethnicity and age. Favorable CVH was less likely to be associated with elevated RHR irrespective of sex, race/ethnicity and age. More research is needed to explore the usefulness of promoting ideal CVH to reduce elevated RHR, a known risk factor for CVD.
AB - Elevated resting heart rate (RHR) is associated with an increased cardiovascular disease (CVD) risk, but little is known about its association with cardiovascular health (CVH), assessed by the Life's Simple 7 (LS7) metrics. We explored whether ideal CVH was associated with RHR in a cohort free from clinical CVD. We conducted a cross-sectional analysis of baseline data (2000−2002) of 6457 Multi-Ethnic Study of Atherosclerosis participants in 2018. Each LS7 metric (smoking, physical activity, diet, body mass index, blood pressure, cholesterol and glucose) was scored 0–2. Total score ranged from 0 to 14. Scores of 0–8 indicate inadequate, 9–10 average, and 11–14 optimal CVH. RHR was categorized as <60, 60–69, 70–79 and ≥80 bpm. We used multinomial logistic regression to determine associations between CVH score and RHR, adjusting for age, sex, race/ethnicity, education, income, health insurance, and atrioventricular nodal blockers. Mean age of participants (standard deviation) was 62 (10) years; 53% were women; 47% had inadequate CVH, 33% average, and 20% optimal. Favorable CVH was associated with lower odds of having higher RHR. Compared to RHR <60 bpm, participants with optimal CVH had adjusted odds ratio (95% CI) of 0.55 (0.46–0.64) for RHR of 60-69 bpm, 0.34 (0.28–0.43) for 70–79 bpm, and 0.14 (0.09–0.22) for ≥80 bpm. A similar pattern was observed in the stratified analysis by sex, race/ethnicity and age. Favorable CVH was less likely to be associated with elevated RHR irrespective of sex, race/ethnicity and age. More research is needed to explore the usefulness of promoting ideal CVH to reduce elevated RHR, a known risk factor for CVD.
KW - Ideal cardiovascular health metrics
KW - Life's simple 7
KW - Prevention
KW - Resting heart rate
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UR - http://www.scopus.com/inward/citedby.url?scp=85075041188&partnerID=8YFLogxK
U2 - 10.1016/j.ypmed.2019.105890
DO - 10.1016/j.ypmed.2019.105890
M3 - Article
C2 - 31715219
AN - SCOPUS:85075041188
SN - 0091-7435
VL - 130
JO - Preventive Medicine
JF - Preventive Medicine
M1 - 105890
ER -