Abstract
Enterovirus D68 (EV-D68) is a member of the Picornaviridae family. Although EV-D68-associated infection was once considered rare, it has been increasing in recent years. EV-D68 infection is most frequently associated with respiratory illness. However, it has also been implicated in a polio-like neurological disorder, acute flaccid myelitis. Although sialic acid has been implicated in EV-D68 entry, the existence of a protein receptor has yet to be clarified. Here we identify neuron-specific intercellular adhesion molecule 5 (ICAM-5/telencephalin) as a cellular receptor for sialic acid-dependent and -independent EV-D68 viruses. EV-D68 bound specifically and efficiently to ICAM-5, and replication of EV-D68 in diverse cell types was inhibited by soluble ICAM-5 fragments. ICAM-5 silencing attenuated EV-D68 replication in permissive cells, and ICAM-5 expression in non-permissive cells allowed EV-D68 replication. The discovery of a neuron-specific adhesion molecule as an EV-D68 receptor has important implications for EV-D68 pathogenesis and may facilitate the development of novel intervention strategies.
Original language | English (US) |
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Pages (from-to) | 631-641 |
Number of pages | 11 |
Journal | Cell Host and Microbe |
Volume | 20 |
Issue number | 5 |
DOIs | |
State | Published - Nov 9 2016 |
Keywords
- EV-D68
- ICAM-5/telencephalin
- acute flaccid myelitis
- enterovirus
- entry receptor
- picornaviridae
- respiratory illness
ASJC Scopus subject areas
- Parasitology
- Microbiology
- Virology