Ibotenic acid lesions of the medial prefrontal cortex potentiate FG-7142-induced attenuation of exploratory activity in the rat

George E. Jaskiw; Daniel R. Weinberger

doi:10.1016/0091-3057(90)90276-N

Ibotenic acid lesions of the medial prefrontal cortex potentiate FG-7142-induced attenuation of exploratory activity in the rat

George E. Jaskiw, Daniel R. Weinberger

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

Six weeks after induction of bilateral sham or ibotenic acid lesions of the medial prefrontal cortex (MPFC), groups of rats were injected with the anxiogenic β-carboline FG-7142 (15 mg/kg IP) or vehicle (VEH) before exposure to a novel open field. The attenuation of exploratory activity by FG-7142 was markedly enchanced in the MPFC-lesioned rats. The results suggest that the behavioral effects of MPFC lesions may be amplified under stressful conditions. Secondly, the inhibition of exploratory activity by FG-7142 does not depend on its action within the MPFC.

Original language	English (US)
Pages (from-to)	695-697
Number of pages	3
Journal	Pharmacology, Biochemistry and Behavior
Volume	36
Issue number	3
DOIs	https://doi.org/10.1016/0091-3057(90)90276-N
State	Published - Jul 1990
Externally published	Yes

Keywords

Exploration
FG-7142
Ibotenic acid
Locomotion
Prefrontal cortex
Stress

ASJC Scopus subject areas

Biochemistry
Toxicology
Pharmacology
Clinical Biochemistry
Biological Psychiatry
Behavioral Neuroscience

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10.1016/0091-3057(90)90276-N

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title = "Ibotenic acid lesions of the medial prefrontal cortex potentiate FG-7142-induced attenuation of exploratory activity in the rat",

abstract = "Six weeks after induction of bilateral sham or ibotenic acid lesions of the medial prefrontal cortex (MPFC), groups of rats were injected with the anxiogenic β-carboline FG-7142 (15 mg/kg IP) or vehicle (VEH) before exposure to a novel open field. The attenuation of exploratory activity by FG-7142 was markedly enchanced in the MPFC-lesioned rats. The results suggest that the behavioral effects of MPFC lesions may be amplified under stressful conditions. Secondly, the inhibition of exploratory activity by FG-7142 does not depend on its action within the MPFC.",

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AU - Jaskiw, George E.

AU - Weinberger, Daniel R.

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Y1 - 1990/7

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AB - Six weeks after induction of bilateral sham or ibotenic acid lesions of the medial prefrontal cortex (MPFC), groups of rats were injected with the anxiogenic β-carboline FG-7142 (15 mg/kg IP) or vehicle (VEH) before exposure to a novel open field. The attenuation of exploratory activity by FG-7142 was markedly enchanced in the MPFC-lesioned rats. The results suggest that the behavioral effects of MPFC lesions may be amplified under stressful conditions. Secondly, the inhibition of exploratory activity by FG-7142 does not depend on its action within the MPFC.

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KW - FG-7142

KW - Ibotenic acid

KW - Locomotion

KW - Prefrontal cortex

KW - Stress

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Ibotenic acid lesions of the medial prefrontal cortex potentiate FG-7142-induced attenuation of exploratory activity in the rat

Abstract

Keywords

ASJC Scopus subject areas

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