Ibotenic acid lesions of the medial prefrontal cortex potentiate FG-7142-induced attenuation of exploratory activity in the rat

George E. Jaskiw, Daniel R. Weinberger

Research output: Contribution to journalArticle

Abstract

Six weeks after induction of bilateral sham or ibotenic acid lesions of the medial prefrontal cortex (MPFC), groups of rats were injected with the anxiogenic β-carboline FG-7142 (15 mg/kg IP) or vehicle (VEH) before exposure to a novel open field. The attenuation of exploratory activity by FG-7142 was markedly enchanced in the MPFC-lesioned rats. The results suggest that the behavioral effects of MPFC lesions may be amplified under stressful conditions. Secondly, the inhibition of exploratory activity by FG-7142 does not depend on its action within the MPFC.

Original languageEnglish (US)
Pages (from-to)695-697
Number of pages3
JournalPharmacology, Biochemistry and Behavior
Volume36
Issue number3
DOIs
StatePublished - Jul 1990
Externally publishedYes

Keywords

  • Exploration
  • FG-7142
  • Ibotenic acid
  • Locomotion
  • Prefrontal cortex
  • Stress

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

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