Ibotenic acid lesions of medial prefrontal cortex augment swim-stress-induced locomotion

George E. Jaskiw, Daniel R. Weinberger

Research output: Contribution to journalArticle


Locomotor activity of rats with sham or ibotenic acid lesions of the medial prefrontal cortex (MPFC) was assessed after animals were exposed to a 15-min swim or control stress. Swim-stress-induced locomotor activity was augmented in the MPFC-lesioned rats. These and other data suggest that lesions of the MPFC are followed by an exaggeration of the normal behavioral response to stress. Dysregulation of dopamine transmission in the basal ganglia may be involved.

Original languageEnglish (US)
Pages (from-to)607-609
Number of pages3
JournalPharmacology, Biochemistry and Behavior
Issue number3
StatePublished - Mar 1992
Externally publishedYes



  • Dopamine
  • Ibotenic acid
  • Locomotion
  • Prefrontal cortex
  • Rat
  • Stress
  • Swim

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

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