I‐125 and I‐123 labelled iodobenzyl bromide, a useful alkylating agent for radiolabelling biologically important molecules

Alan A. Wilson, Robert F. Dannals, Hayden T. Ravert, H. Donald Burns, Henry N. Wagner

Research output: Contribution to journalArticlepeer-review

Abstract

The radioiodination of 4‐trimethylsilylbenzyl bromide in acetic acid with no carrier added I‐125 and I‐123 iodide ion and N‐chlorosuccinimide (NCS) is a rapid, high yielding process which produces high specific activity 4‐[I‐125 or I‐123]iodobenzyl bromide. This radiolabelled alkylating agent has been efficiently reacted with N,N‐dimethylaniline and triphenylphosphine to generate radiolabelled quaternary ammonium and phosphonium salts, and should be useful for labelling other biologically important molecules which possess suitable nucleophilic functional groups.

Original languageEnglish (US)
Pages (from-to)83-93
Number of pages11
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Volume23
Issue number1
DOIs
StatePublished - Jan 1986

Keywords

  • 4‐iodobenzyl bromide
  • 4‐trimethylsilylbenzyl bromide
  • I‐123
  • I‐125
  • Radioiodination
  • lipophilic cations

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Radiology Nuclear Medicine and imaging
  • Drug Discovery
  • Spectroscopy
  • Organic Chemistry

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