TY - JOUR
T1 - IκB Family Members Function by Different Mechanisms
AU - Tam, Winnie F.
AU - Sen, Ranjan
PY - 2001/3/16
Y1 - 2001/3/16
N2 - The IκB family of proteins regulates NF-κB-dependent transcription by inhibiting DNA binding and localizing these factors to the cell cytoplasm. IκBα does this by shifting the balance between nuclear import of Rel proteins and their export from the nucleus. Here we show that, unlike IκBα, IκBβ and IκBε appear to sequester p65 or c-Rel in the cytoplasm by inhibiting nuclear import. Furthermore, because IκBβ does not undergo nucleocytoplasmic shuttling, it cannot remove nuclear proteins like IκBα does. We conclude that the mechanism of action differs among IκB family members.
AB - The IκB family of proteins regulates NF-κB-dependent transcription by inhibiting DNA binding and localizing these factors to the cell cytoplasm. IκBα does this by shifting the balance between nuclear import of Rel proteins and their export from the nucleus. Here we show that, unlike IκBα, IκBβ and IκBε appear to sequester p65 or c-Rel in the cytoplasm by inhibiting nuclear import. Furthermore, because IκBβ does not undergo nucleocytoplasmic shuttling, it cannot remove nuclear proteins like IκBα does. We conclude that the mechanism of action differs among IκB family members.
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U2 - 10.1074/jbc.C000916200
DO - 10.1074/jbc.C000916200
M3 - Article
C2 - 11152669
AN - SCOPUS:0035896543
SN - 0021-9258
VL - 276
SP - 7701
EP - 7704
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 11
ER -