IκB Family Members Function by Different Mechanisms

Winnie F. Tam, Ranjan Sen

Research output: Contribution to journalArticlepeer-review


The IκB family of proteins regulates NF-κB-dependent transcription by inhibiting DNA binding and localizing these factors to the cell cytoplasm. IκBα does this by shifting the balance between nuclear import of Rel proteins and their export from the nucleus. Here we show that, unlike IκBα, IκBβ and IκBε appear to sequester p65 or c-Rel in the cytoplasm by inhibiting nuclear import. Furthermore, because IκBβ does not undergo nucleocytoplasmic shuttling, it cannot remove nuclear proteins like IκBα does. We conclude that the mechanism of action differs among IκB family members.

Original languageEnglish (US)
Pages (from-to)7701-7704
Number of pages4
JournalJournal of Biological Chemistry
Issue number11
StatePublished - Mar 16 2001
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry

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