Hypoxic regulation of ion channels and transporters in pulmonary vascular smooth muscle

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Exposure to prolonged alveolar hypoxia, as occurs with many chronic lung diseases or residence at high altitude, results in the development of pulmonary hypertension, significantly worsening patient prognosis. While the structural and functional changes that occur in the pulmonary vasculature in response to chronic hypoxia have been well characterized, less is known regarding the cellular mechanisms underlying this process. The use of animals models of hypoxic pulmonary hypertension have provided important insights into the changes that occur in the pulmonary vascular smooth muscle cells and some of the mediators involved. In this chapter, the effect of chronic hypoxia on various pulmonary arterial smooth muscle cell ion channels and transporters, and the role of the transcription factor, hypoxia-inducible factor 1, in regulating these changes, will be discussed.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
Pages221-235
Number of pages15
Volume661
DOIs
StatePublished - 2010

Publication series

NameAdvances in Experimental Medicine and Biology
Volume661
ISSN (Print)00652598

Fingerprint

Ion Channels
Vascular Smooth Muscle
Muscle
Cells
Pulmonary Hypertension
Hypoxia-Inducible Factor 1
Lung
Pulmonary diseases
Smooth Muscle Myocytes
Animals
Transcription Factors
Lung Diseases
Chronic Disease
Animal Models
Hypoxia

Keywords

  • Chronic hypoxia
  • Hypoxia-inducible factor 1
  • Hypoxic pulmonary hypertension
  • Intracellular calcium
  • Intracellular pH
  • Na+/H+ exchanger
  • Pulmonary vascular smooth muscle

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Shimoda, L. (2010). Hypoxic regulation of ion channels and transporters in pulmonary vascular smooth muscle. In Advances in Experimental Medicine and Biology (Vol. 661, pp. 221-235). (Advances in Experimental Medicine and Biology; Vol. 661). https://doi.org/10.1007/978-1-60761-500-2_14

Hypoxic regulation of ion channels and transporters in pulmonary vascular smooth muscle. / Shimoda, Larissa.

Advances in Experimental Medicine and Biology. Vol. 661 2010. p. 221-235 (Advances in Experimental Medicine and Biology; Vol. 661).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Shimoda, L 2010, Hypoxic regulation of ion channels and transporters in pulmonary vascular smooth muscle. in Advances in Experimental Medicine and Biology. vol. 661, Advances in Experimental Medicine and Biology, vol. 661, pp. 221-235. https://doi.org/10.1007/978-1-60761-500-2_14
Shimoda L. Hypoxic regulation of ion channels and transporters in pulmonary vascular smooth muscle. In Advances in Experimental Medicine and Biology. Vol. 661. 2010. p. 221-235. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-1-60761-500-2_14
Shimoda, Larissa. / Hypoxic regulation of ion channels and transporters in pulmonary vascular smooth muscle. Advances in Experimental Medicine and Biology. Vol. 661 2010. pp. 221-235 (Advances in Experimental Medicine and Biology).
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