Hypoxic regulation of ion channels and transporters in pulmonary vascular smooth muscle

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Exposure to prolonged alveolar hypoxia, as occurs with many chronic lung diseases or residence at high altitude, results in the development of pulmonary hypertension, significantly worsening patient prognosis. While the structural and functional changes that occur in the pulmonary vasculature in response to chronic hypoxia have been well characterized, less is known regarding the cellular mechanisms underlying this process. The use of animals models of hypoxic pulmonary hypertension have provided important insights into the changes that occur in the pulmonary vascular smooth muscle cells and some of the mediators involved. In this chapter, the effect of chronic hypoxia on various pulmonary arterial smooth muscle cell ion channels and transporters, and the role of the transcription factor, hypoxia-inducible factor 1, in regulating these changes, will be discussed.

Original languageEnglish (US)
Title of host publicationMembrane Receptors, Channels and Transporters in Pulmonary Circulation
EditorsJ.X.J Yuan, J.P.T. Ward
Pages221-235
Number of pages15
DOIs
StatePublished - Dec 1 2010

Publication series

NameAdvances in Experimental Medicine and Biology
Volume661
ISSN (Print)0065-2598

Keywords

  • Chronic hypoxia
  • Hypoxia-inducible factor 1
  • Hypoxic pulmonary hypertension
  • Intracellular calcium
  • Intracellular pH
  • Na+/H+ exchanger
  • Pulmonary vascular smooth muscle

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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