Hypoxic-Ischemic Encephalopathy in the Term Infant

Research output: Contribution to journalReview articlepeer-review


Hypoxia-ischemia in the perinatal period is an important cause of cerebral palsy and associated disabilities in children. There has been significant research progress in hypoxic-ischemic encephalopathy over the last 2 decades, and many new molecular mechanisms have been identified. Despite all these advances, therapeutic interventions are still limited. In this article the authors discuss several molecular pathways involved in hypoxia-ischemia, and potential therapeutic targets.

Original languageEnglish (US)
Pages (from-to)835-858
Number of pages24
JournalClinics in Perinatology
Issue number4
StatePublished - Dec 2009


  • Apoptosis
  • Hypothermia
  • Hypoxia-ischemia
  • Neonatal encephalopathy
  • Oxidative stress

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology


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