Hypoxic-ischemic brain injury in neonatal piglets with different histological outcomes: An amplitude-integrated EEG study

Dandan Zhang, Manan Hathi, Zeng Jin Yang, Haiyan Ding, Raymond C Koehler, Nitish V Thakor

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

To test the reliability of amplitude-integrated electroencephalogram (aEEG) in cerebral hypoxic ischemia (HI), 12 neonatal piglets subjected to different levels of HI are divided into three groups based on the histological outcomes obtained 4 days after experiment. Results show that concomitant with the increased severity of brain injury, the upper and lower margins of aEEG decrease significantly (p <0.05) during early recovery period after HI (about 2 hours post-resuscitation). We conclude that aEEG method reliably reflects hypoxic-ischemic cerebral injury and constitutes a valuable monitoring tool in neonatal intensive care unit (NICU).

Original languageEnglish (US)
Title of host publicationProceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009
Pages1127-1130
Number of pages4
DOIs
StatePublished - 2009
Event31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009 - Minneapolis, MN, United States
Duration: Sep 2 2009Sep 6 2009

Other

Other31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009
CountryUnited States
CityMinneapolis, MN
Period9/2/099/6/09

Fingerprint

Electroencephalography
Brain Injuries
Brain
Ischemia
Resuscitation
Intensive care units
Neonatal Intensive Care Units
Brain Ischemia
Recovery
Monitoring
Wounds and Injuries
Experiments

ASJC Scopus subject areas

  • Cell Biology
  • Developmental Biology
  • Biomedical Engineering
  • Medicine(all)

Cite this

Zhang, D., Hathi, M., Yang, Z. J., Ding, H., Koehler, R. C., & Thakor, N. V. (2009). Hypoxic-ischemic brain injury in neonatal piglets with different histological outcomes: An amplitude-integrated EEG study. In Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009 (pp. 1127-1130). [5333439] https://doi.org/10.1109/IEMBS.2009.5333439

Hypoxic-ischemic brain injury in neonatal piglets with different histological outcomes : An amplitude-integrated EEG study. / Zhang, Dandan; Hathi, Manan; Yang, Zeng Jin; Ding, Haiyan; Koehler, Raymond C; Thakor, Nitish V.

Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009. 2009. p. 1127-1130 5333439.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Zhang, D, Hathi, M, Yang, ZJ, Ding, H, Koehler, RC & Thakor, NV 2009, Hypoxic-ischemic brain injury in neonatal piglets with different histological outcomes: An amplitude-integrated EEG study. in Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009., 5333439, pp. 1127-1130, 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009, Minneapolis, MN, United States, 9/2/09. https://doi.org/10.1109/IEMBS.2009.5333439
Zhang D, Hathi M, Yang ZJ, Ding H, Koehler RC, Thakor NV. Hypoxic-ischemic brain injury in neonatal piglets with different histological outcomes: An amplitude-integrated EEG study. In Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009. 2009. p. 1127-1130. 5333439 https://doi.org/10.1109/IEMBS.2009.5333439
Zhang, Dandan ; Hathi, Manan ; Yang, Zeng Jin ; Ding, Haiyan ; Koehler, Raymond C ; Thakor, Nitish V. / Hypoxic-ischemic brain injury in neonatal piglets with different histological outcomes : An amplitude-integrated EEG study. Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009. 2009. pp. 1127-1130
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