Hypoxia, Not the Frequency of Sleep Apnea, Induces Acute Hemodynamic Stress in Patients With Chronic Heart Failure

Joshua D. Gottlieb, Alan R Schwartz, Joanne Marshall, Pamela Ouyang, Linda Kern, Veena Shetty, Maria Trois, Naresh M Punjabi, Cynthia Brown, Samer S. Najjar, Stephen S. Gottlieb

Research output: Contribution to journalArticle

Abstract

Objectives: This study was conducted to evaluate whether brain (B-type) natriuretic peptide (BNP) changes during sleep are associated with the frequency and severity of apneic/hypopneic episodes, intermittent arousals, and hypoxia. Background: Sleep apnea is strongly associated with heart failure (HF) and could conceivably worsen HF through increased sympathetic activity, hemodynamic stress, hypoxemia, and oxidative stress. If apneic activity does cause acute stress in HF, it should increase BNP. Methods: Sixty-four HF patients with New York Heart Association functional class II and III HF and ejection fraction

Original languageEnglish (US)
Pages (from-to)1706-1712
Number of pages7
JournalJournal of the American College of Cardiology
Volume54
Issue number18
DOIs
StatePublished - Oct 27 2009

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Sleep Apnea Syndromes
Heart Failure
Hemodynamics
Brain Natriuretic Peptide
Arousal
Sleep
Oxidative Stress
Hypoxia

Keywords

  • brain natriuretic peptide
  • hypoxia
  • sleep apnea

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Hypoxia, Not the Frequency of Sleep Apnea, Induces Acute Hemodynamic Stress in Patients With Chronic Heart Failure. / Gottlieb, Joshua D.; Schwartz, Alan R; Marshall, Joanne; Ouyang, Pamela; Kern, Linda; Shetty, Veena; Trois, Maria; Punjabi, Naresh M; Brown, Cynthia; Najjar, Samer S.; Gottlieb, Stephen S.

In: Journal of the American College of Cardiology, Vol. 54, No. 18, 27.10.2009, p. 1706-1712.

Research output: Contribution to journalArticle

Gottlieb, JD, Schwartz, AR, Marshall, J, Ouyang, P, Kern, L, Shetty, V, Trois, M, Punjabi, NM, Brown, C, Najjar, SS & Gottlieb, SS 2009, 'Hypoxia, Not the Frequency of Sleep Apnea, Induces Acute Hemodynamic Stress in Patients With Chronic Heart Failure', Journal of the American College of Cardiology, vol. 54, no. 18, pp. 1706-1712. https://doi.org/10.1016/j.jacc.2009.08.016
Gottlieb, Joshua D. ; Schwartz, Alan R ; Marshall, Joanne ; Ouyang, Pamela ; Kern, Linda ; Shetty, Veena ; Trois, Maria ; Punjabi, Naresh M ; Brown, Cynthia ; Najjar, Samer S. ; Gottlieb, Stephen S. / Hypoxia, Not the Frequency of Sleep Apnea, Induces Acute Hemodynamic Stress in Patients With Chronic Heart Failure. In: Journal of the American College of Cardiology. 2009 ; Vol. 54, No. 18. pp. 1706-1712.
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AU - Kern, Linda

AU - Shetty, Veena

AU - Trois, Maria

AU - Punjabi, Naresh M

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