Abstract
AIM: To observe altered expression of glutamate transporter EAAT1 after hypoxia-ischemia (H-I) in newborn rat brain. METHODS: Expression levels of EAAT1 were detected with immunohistochemistry method. RESULTS: EAAT1 was a little expressed in cerebral cortex at sham-operated group [(36 ± 10) cells/slice]. Its expression in cerebral cortex increased at 24 h and 48 h following H-I [(314 ± 162) cells/slice and (431 ± 149) cells/slice, respectively], and recovered to control level at 72 h following H-I [(52 ± 8) cells/slice]. The expression of EAAT1 in the ipsilateral cortex to common carotid artery (CCA) ligation was higher than that in the contralateral cortex. CONCLUSION: After H-I, the expression of EAAT1 had a temporal change in cerebral cortex of newborn rat, and was mainly located in the ipsilateral cortex to CCA ligation.
Original language | English (US) |
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Pages (from-to) | 107-111 |
Number of pages | 5 |
Journal | Acta Pharmacologica Sinica |
Volume | 20 |
Issue number | 2 |
State | Published - Feb 24 1999 |
Keywords
- Anoxia
- Carder proteins
- Cerebral cortex
- Cerebral ischemia
- Glutamates
- Immunohistochemistry
ASJC Scopus subject areas
- Pharmacology
- Pharmacology (medical)