Hypoxia-ischemia altered expression of glutamate transporter EAAT1 in neonatal rat brain

Feng Tao, Ling Mei Zhang, Feng Yan Sun

Research output: Contribution to journalArticle

Abstract

AIM: To observe altered expression of glutamate transporter EAAT1 after hypoxia-ischemia (H-I) in newborn rat brain. METHODS: Expression levels of EAAT1 were detected with immunohistochemistry method. RESULTS: EAAT1 was a little expressed in cerebral cortex at sham-operated group [(36 ± 10) cells/slice]. Its expression in cerebral cortex increased at 24 h and 48 h following H-I [(314 ± 162) cells/slice and (431 ± 149) cells/slice, respectively], and recovered to control level at 72 h following H-I [(52 ± 8) cells/slice]. The expression of EAAT1 in the ipsilateral cortex to common carotid artery (CCA) ligation was higher than that in the contralateral cortex. CONCLUSION: After H-I, the expression of EAAT1 had a temporal change in cerebral cortex of newborn rat, and was mainly located in the ipsilateral cortex to CCA ligation.

Original languageEnglish (US)
Pages (from-to)107-111
Number of pages5
JournalActa Pharmacologica Sinica
Volume20
Issue number2
StatePublished - Feb 24 1999

Keywords

  • Anoxia
  • Carder proteins
  • Cerebral cortex
  • Cerebral ischemia
  • Glutamates
  • Immunohistochemistry

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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