Hypoxia-inducible factors promote breast cancer stem cell specification and maintenance in response to hypoxia or cytotoxic chemotherapy

Lisha Xiang, Gregg L. Semenza

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Clinical studies have revealed that breast cancers contain regions of intratumoral hypoxia (reduced oxygen availability), which activates hypoxia-inducible factors (HIFs). The relationship between intratumoral hypoxia, distant metastasis and cancer mortality has been well established. A major mechanism by which intratumoral hypoxia contributes to disease progression is through induction of the breast cancer stem cell (BCSC) phenotype. BCSCs are a small subpopulation of cells with the capability for self-renewal. BCSCs have been implicated in resistance to chemotherapy, disease recurrence, and metastasis. In this review, we will discuss our current understanding of the molecular mechanisms underlying HIF-dependent induction of the BCSC phenotype in response to hypoxia or chemotherapy.

Original languageEnglish (US)
Title of host publicationCancer Stem Cells
EditorsCurt I. Civin, Tami J. Kingsbury, MinJung Kim, Paul B. Fisher
PublisherAcademic Press Inc.
Pages175-212
Number of pages38
ISBN (Print)9780128149942
DOIs
StatePublished - Jan 1 2019

Publication series

NameAdvances in Cancer Research
Volume141
ISSN (Print)0065-230X
ISSN (Electronic)2162-5557

Keywords

  • Breast cancer
  • Chemotherapy
  • Intratumoral hypoxia
  • Metabolism
  • Metastasis
  • Nanog
  • Pluripotency factor
  • Relapse
  • Self-renewal
  • Stem cell

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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