Hypoxia-Inducible Factors and Cancer

Jonathan C. Jun; Aman Rathore; Haris Younas; Daniele Gilkes; Vsevolod Y. Polotsky

doi:10.1007/s40675-017-0062-7

Hypoxia-Inducible Factors and Cancer

Jonathan C. Jun, Aman Rathore, Haris Younas, Daniele Gilkes, Vsevolod Y. Polotsky

School of Medicine

Research output: Contribution to journal › Review article › peer-review

51 Scopus citations

Abstract

Purpose of Review: Hypoxia-inducible factors (HIFs) mediate the transcription of hundreds of genes that allow cells to adapt to hypoxic environments. In this review, we summarize the current state of knowledge about mechanisms of HIF activation in cancer, as well as downstream cancer-promoting consequences such as altered substrate metabolism, angiogenesis, and cell differentiation. In addition, we examine the proposed relationship between respiratory-related hypoxia, HIFs, and cancer. Recent Findings: HIFs are increased in many forms of cancer and portend a poor prognosis and response to therapy. Summary: HIFs play a critical role in various stages of carcinogenesis. HIF and its transcription targets may be useful as biomarkers of disease and therapeutic targets for cancer.

Original language	English (US)
Journal	Current Sleep Medicine Reports
Volume	3
Issue number	1
DOIs	https://doi.org/10.1007/s40675-017-0062-7
State	Published - Mar 1 2017

Keywords

Cancer
HIF
Hypoxia
Metabolism
Sleep apnea
VEGF

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine
Neurology
Clinical Neurology

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10.1007/s40675-017-0062-7

Cite this

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title = "Hypoxia-Inducible Factors and Cancer",

abstract = "Purpose of Review: Hypoxia-inducible factors (HIFs) mediate the transcription of hundreds of genes that allow cells to adapt to hypoxic environments. In this review, we summarize the current state of knowledge about mechanisms of HIF activation in cancer, as well as downstream cancer-promoting consequences such as altered substrate metabolism, angiogenesis, and cell differentiation. In addition, we examine the proposed relationship between respiratory-related hypoxia, HIFs, and cancer. Recent Findings: HIFs are increased in many forms of cancer and portend a poor prognosis and response to therapy. Summary: HIFs play a critical role in various stages of carcinogenesis. HIF and its transcription targets may be useful as biomarkers of disease and therapeutic targets for cancer.",

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AU - Jun, Jonathan C.

AU - Rathore, Aman

AU - Younas, Haris

AU - Gilkes, Daniele

AU - Polotsky, Vsevolod Y.

PY - 2017/3/1

Y1 - 2017/3/1

N2 - Purpose of Review: Hypoxia-inducible factors (HIFs) mediate the transcription of hundreds of genes that allow cells to adapt to hypoxic environments. In this review, we summarize the current state of knowledge about mechanisms of HIF activation in cancer, as well as downstream cancer-promoting consequences such as altered substrate metabolism, angiogenesis, and cell differentiation. In addition, we examine the proposed relationship between respiratory-related hypoxia, HIFs, and cancer. Recent Findings: HIFs are increased in many forms of cancer and portend a poor prognosis and response to therapy. Summary: HIFs play a critical role in various stages of carcinogenesis. HIF and its transcription targets may be useful as biomarkers of disease and therapeutic targets for cancer.

AB - Purpose of Review: Hypoxia-inducible factors (HIFs) mediate the transcription of hundreds of genes that allow cells to adapt to hypoxic environments. In this review, we summarize the current state of knowledge about mechanisms of HIF activation in cancer, as well as downstream cancer-promoting consequences such as altered substrate metabolism, angiogenesis, and cell differentiation. In addition, we examine the proposed relationship between respiratory-related hypoxia, HIFs, and cancer. Recent Findings: HIFs are increased in many forms of cancer and portend a poor prognosis and response to therapy. Summary: HIFs play a critical role in various stages of carcinogenesis. HIF and its transcription targets may be useful as biomarkers of disease and therapeutic targets for cancer.

KW - Cancer

KW - HIF

KW - Hypoxia

KW - Metabolism

KW - Sleep apnea

KW - VEGF

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Hypoxia-Inducible Factors and Cancer

Abstract

Keywords

ASJC Scopus subject areas

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