Hypoxia-inducible factor-1-dependent mechanisms of vascularization and vascular remodelling

Sergio Rey, Gregg L. Semenza

Research output: Contribution to journalReview articlepeer-review

Abstract

The vascular system delivers oxygen and nutrients to every cell in the vertebrate organism. Hypoxia-inducible factor 1 (HIF-1) is a master regulator of hypoxic/ischaemic vascular responses, driving transcriptional activation of hundreds of genes involved in vascular reactivity, angiogenesis, arteriogenesis, and the mobilization and homing of bone marrow-derived angiogenic cells. This review will focus on the pivotal role of HIF-1 in vascular homeostasis, the involvement of HIF-1 in vascular diseases, and recent advances in targeting HIF-1 for therapy in preclinical models.

Original languageEnglish (US)
Pages (from-to)236-242
Number of pages7
JournalCardiovascular research
Volume86
Issue number2
DOIs
StatePublished - May 2010

Keywords

  • Angiogenesis
  • Cell therapy
  • Gene therapy
  • HIF-1
  • Hypoxia
  • Vascularization

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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