Abstract
Hypoxia-inducible factor 1 (HIF-1) is a transcriptional activator that mediates changes in gene expression in response to changes in cellular oxygen concentrations. HIF-1 is a heterodimer consisting of an oxygen-regulated HIF-1α subunit and a constitutively expressed HIF-1β subunit. In mice, complete HIF-1α deficiency results in embryonic lethality at midgestation because of cardiac and vascular malformations. Analyses of animal and cell culture models as well as human tissue have provided evidence that HIF-1 plays important roles in the pathophysiology of preeclampsia, intrauterine growth retardation, hypoxia-mediated pulmonary hypertension, and cancer. HIF-1 promotes neovascularization in response to myocardial or retinal ischemia by activating transcription of the gene encoding vascular endothelial growth factor. HIF-1 may also mediate the protective response to cerebral ischemia known as late-phase preconditioning.
Original language | English (US) |
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Pages (from-to) | 614-617 |
Number of pages | 4 |
Journal | Pediatric research |
Volume | 49 |
Issue number | 5 |
DOIs | |
State | Published - 2001 |
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health