| Original language | English (US) |
|---|---|
| Pages (from-to) | 207-214 |
| Number of pages | 8 |
| Journal | Journal of Laboratory and Clinical Medicine |
| Volume | 131 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 1998 |
ASJC Scopus subject areas
- Pathology and Forensic Medicine
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In: Journal of Laboratory and Clinical Medicine, Vol. 131, No. 3, 03.1998, p. 207-214.
Research output: Contribution to journal › Review article › peer-review
}
TY - JOUR
T1 - Hypoxia-inducible factor 1 and the molecular physiology of oxygen homeostasis
AU - Semenza, Gregg L.
N1 - Funding Information: All mammalian cells can sense changes in 0 2 concentration and respond to hypoxia with changes in gene expression, which are necessary for all sustained alterations in cellular function and structure. How do cells sense changes in 02 concentration? Once the signal (hypoxia) is received, how is it transmitted to the nucleus? How is gene expression modulated in response to the signal? Are there cell-type differences in one or more of these signal transduction components? The fundamental biologic importance of 02 suggests that mechanisms for sensing and responding to hypoxia are likely to be From the Center for Medical Genetics, Departments of Pediatrics and Medicine, The Johns Hopkins University School of Medicine. Supported in part by Grants R01-DK39869 and R01-HL55338 from the National Institutes of Health. G. L. S. is an Established Investigator of the American Heart Association. Submitted for publication July 15, 1997; accepted July 15, 1997. Reprint requests: Gregg L. Semenza, MD, PhD, Johns Hopkins Hospital, CMSC-1004, 600 North Wolfe Street, Baltimore, MD 21287-3914. J Lab Clin Med 1998;131:207-14. Copyright © 1998 by Mosby, Inc. 0022-2143/98 $5.00 + 0 5/1/87248 exceedingly complex. This review will focus on one component of this complex biologic response, hypoxia-inducible factor 1 (HIF-1), a nuclear protein that activates gene transcription specifically in response to reduced cellular 0 2 concentration. Recent advances in the molecular biology of HIF-1 will be described and interpreted in the contexts of cellular and systemic physiology and human disease.
PY - 1998/3
Y1 - 1998/3
UR - http://www.scopus.com/inward/record.url?scp=0032033086&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032033086&partnerID=8YFLogxK
U2 - 10.1016/S0022-2143(98)90091-9
DO - 10.1016/S0022-2143(98)90091-9
M3 - Review article
C2 - 9523843
AN - SCOPUS:0032033086
SN - 0022-2143
VL - 131
SP - 207
EP - 214
JO - Journal of Laboratory and Clinical Medicine
JF - Journal of Laboratory and Clinical Medicine
IS - 3
ER -