Hypoxia-inducible factor 1 and cancer pathogenesis

Research output: Contribution to journalReview article

Abstract

Hypoxia-inducible factor 1 (HIF-1) is a transcriptional activator that mediates adaptive responses to hypoxia. HIF-1 activity is increased in the majority of human cancers as a result of genetic alterations and intratumoral hypoxia. HIF-1 activates the transcription of genes that increase O2 availability by stimulating angiogenesis or that reprogram cellular metabolism to adapt to reduced O2 availability. Proof of principle studies in mouse models suggests that inhibition of HIF-1 activity may have therapeutic effects, especially in combination with other anticancer drugs.

Original languageEnglish (US)
Pages (from-to)591-597
Number of pages7
JournalIUBMB Life
Volume60
Issue number9
DOIs
StatePublished - Dec 1 2008

Keywords

  • Angiogenesis
  • Autophagy
  • Cancer
  • Glycolysis
  • Hypoxia
  • Mitochondria
  • ROS
  • Respiration

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics
  • Clinical Biochemistry
  • Cell Biology

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