Hypoxia-inducible factor 1 and breast cancer metastasis

Zhao ji Liu, Gregg L. Semenza, Hua feng Zhang

Research output: Contribution to journalReview articlepeer-review


Accumulating evidence has shown that the hypoxic microenvironment, which is critical during cancer development, plays a key role in regulating breast cancer progression and metastasis. The effects of hypoxia-inducible factor 1 (HIF-1), a master regulator of the hypoxic response, have been extensively studied during these processes. In this review, we focus on the roles of HIF-1 in regulating breast cancer cell metastasis, specifically its effects on multiple key steps of metastasis, such as epithelial-mesenchymal transition (EMT), invasion, extravasation, and metastatic niche formation. We also discuss the roles of HIF-1-regulated non-coding RNAs in breast cancer metastasis, and therapeutic opportunities for breast cancer through targeting the HIF-1 pathway.

Original languageEnglish (US)
Pages (from-to)32-43
Number of pages12
JournalJournal of Zhejiang University: Science B
Issue number1
StatePublished - Jan 1 2015


  • Breast cancer
  • Hypoxia-inducible factor 1 (HIF-1)
  • Metastasis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • veterinary(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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