Abstract
Naïve T cells activated by antigen-presenting cells (APC) can be differentiated into at least four major types of T-helper (TH) cells: TH1, TH2, TH17 and inducible regulatory T cells (iTreg) based on their unique cytokine production profiles and characteristic functions.1 TH1 produce interferon-γ (IFNγ) and are important for protective immune responses to intracellular viral, bacterial and parasitic infection. TH2 cells produce interleukin-4 (IL-4), IL-5, IL-23 and are critical for controlling extracellular parasites such as helminthes. TH17 cells are responsible for expelling extracellular bacteria and fungi through secretion of IL-17a, IL-17f and IL-22.2 These cells however are perhaps better known for their propensity to drive autoimmune responses. Tregs including naturally occurring regulatory T cells (nTreg) play important roles in the suppressive control of both innate and adaptive immunity in vivo3,4.
Original language | English (US) |
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Pages (from-to) | 510-515 |
Number of pages | 6 |
Journal | OncoImmunology |
Volume | 1 |
Issue number | 4 |
DOIs | |
State | Published - 2012 |
Keywords
- Cancer
- Hif1
- Hypoxia
- Inflammation
- Metabolism
- T cell differentiation
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Oncology