Hypoxia-inducible factor 1: A link between metabolism and T cell differentiation and a potential therapeutic target

Fan Pan, Joseph Barbi, Drew M. Pardoll

Research output: Contribution to journalArticlepeer-review

Abstract

Naïve T cells activated by antigen-presenting cells (APC) can be differentiated into at least four major types of T-helper (TH) cells: TH1, TH2, TH17 and inducible regulatory T cells (iTreg) based on their unique cytokine production profiles and characteristic functions.1 TH1 produce interferon-γ (IFNγ) and are important for protective immune responses to intracellular viral, bacterial and parasitic infection. TH2 cells produce interleukin-4 (IL-4), IL-5, IL-23 and are critical for controlling extracellular parasites such as helminthes. TH17 cells are responsible for expelling extracellular bacteria and fungi through secretion of IL-17a, IL-17f and IL-22.2 These cells however are perhaps better known for their propensity to drive autoimmune responses. Tregs including naturally occurring regulatory T cells (nTreg) play important roles in the suppressive control of both innate and adaptive immunity in vivo3,4.

Original languageEnglish (US)
Pages (from-to)510-515
Number of pages6
JournalOncoImmunology
Volume1
Issue number4
DOIs
StatePublished - 2012

Keywords

  • Cancer
  • Hif1
  • Hypoxia
  • Inflammation
  • Metabolism
  • T cell differentiation

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Oncology

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