Hypoxia-inducible factor 1-α in chronic gastrointestinal ischemia

Jihan Harki, Aria Sana, Désirée van Noord, Paul J. van Diest, Petra van der Groep, Ernst J. Kuipers, Leon M G Moons, Katharina Biermann, Eric T T L Tjwa

Research output: Contribution to journalArticle

Abstract

Chronic gastrointestinal ischemia (CGI) is the result of decreased mucosal perfusion. Typical histological characteristics are lacking which hamper its early diagnosis. Hypoxia-inducible factor-1α (HIF-1α) is expressed under acute hypoxia. We investigated HIF-1α expression in chronic ischemic and inflammatory conditions of the human gastrointestinal (GI) tract. Immunohistochemical expression of HIF-1α was analyzed in 61 patients, including patients with CGI, Helicobacter pylori gastritis, ischemic colitis (IC), infectious colitis, and inflammatory bowel disease (IBD), and 22 controls. HIF-1α expression in >10 % of the cells was regarded as positive staining, and expression

Original languageEnglish (US)
Pages (from-to)125-132
Number of pages8
JournalVirchows Archiv
Volume466
Issue number2
DOIs
StatePublished - 2014
Externally publishedYes

Fingerprint

Hypoxia-Inducible Factor 1
Ischemia
Ischemic Colitis
Gastritis
Colitis
Helicobacter pylori
Gastrointestinal Tract
Early Diagnosis
Perfusion
Staining and Labeling

Keywords

  • Chronic gastrointestinal ischemia
  • Hypoxia
  • Hypoxia-inducible factor-1α
  • Immunohistochemistry
  • Inflammation
  • Ischemic colitis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Cell Biology
  • Molecular Biology
  • Medicine(all)

Cite this

Harki, J., Sana, A., van Noord, D., van Diest, P. J., van der Groep, P., Kuipers, E. J., ... Tjwa, E. T. T. L. (2014). Hypoxia-inducible factor 1-α in chronic gastrointestinal ischemia. Virchows Archiv, 466(2), 125-132. https://doi.org/10.1007/s00428-014-1691-6

Hypoxia-inducible factor 1-α in chronic gastrointestinal ischemia. / Harki, Jihan; Sana, Aria; van Noord, Désirée; van Diest, Paul J.; van der Groep, Petra; Kuipers, Ernst J.; Moons, Leon M G; Biermann, Katharina; Tjwa, Eric T T L.

In: Virchows Archiv, Vol. 466, No. 2, 2014, p. 125-132.

Research output: Contribution to journalArticle

Harki, J, Sana, A, van Noord, D, van Diest, PJ, van der Groep, P, Kuipers, EJ, Moons, LMG, Biermann, K & Tjwa, ETTL 2014, 'Hypoxia-inducible factor 1-α in chronic gastrointestinal ischemia', Virchows Archiv, vol. 466, no. 2, pp. 125-132. https://doi.org/10.1007/s00428-014-1691-6
Harki J, Sana A, van Noord D, van Diest PJ, van der Groep P, Kuipers EJ et al. Hypoxia-inducible factor 1-α in chronic gastrointestinal ischemia. Virchows Archiv. 2014;466(2):125-132. https://doi.org/10.1007/s00428-014-1691-6
Harki, Jihan ; Sana, Aria ; van Noord, Désirée ; van Diest, Paul J. ; van der Groep, Petra ; Kuipers, Ernst J. ; Moons, Leon M G ; Biermann, Katharina ; Tjwa, Eric T T L. / Hypoxia-inducible factor 1-α in chronic gastrointestinal ischemia. In: Virchows Archiv. 2014 ; Vol. 466, No. 2. pp. 125-132.
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