Abstract
Chronic gastrointestinal ischemia (CGI) is the result of decreased mucosal perfusion. Typical histological characteristics are lacking which hamper its early diagnosis. Hypoxia-inducible factor-1α (HIF-1α) is expressed under acute hypoxia. We investigated HIF-1α expression in chronic ischemic and inflammatory conditions of the human gastrointestinal (GI) tract. Immunohistochemical expression of HIF-1α was analyzed in 61 patients, including patients with CGI, Helicobacter pylori gastritis, ischemic colitis (IC), infectious colitis, and inflammatory bowel disease (IBD), and 22 controls. HIF-1α expression in >10 % of the cells was regarded as positive staining, and expression
| Original language | English (US) |
|---|---|
| Pages (from-to) | 125-132 |
| Number of pages | 8 |
| Journal | Virchows Archiv |
| Volume | 466 |
| Issue number | 2 |
| DOIs | |
| State | Published - 2014 |
| Externally published | Yes |
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Keywords
- Chronic gastrointestinal ischemia
- Hypoxia
- Hypoxia-inducible factor-1α
- Immunohistochemistry
- Inflammation
- Ischemic colitis
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Cell Biology
- Molecular Biology
- Medicine(all)
Cite this
Hypoxia-inducible factor 1-α in chronic gastrointestinal ischemia. / Harki, Jihan; Sana, Aria; van Noord, Désirée; van Diest, Paul J.; van der Groep, Petra; Kuipers, Ernst J.; Moons, Leon M G; Biermann, Katharina; Tjwa, Eric T T L.
In: Virchows Archiv, Vol. 466, No. 2, 2014, p. 125-132.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Hypoxia-inducible factor 1-α in chronic gastrointestinal ischemia
AU - Harki, Jihan
AU - Sana, Aria
AU - van Noord, Désirée
AU - van Diest, Paul J.
AU - van der Groep, Petra
AU - Kuipers, Ernst J.
AU - Moons, Leon M G
AU - Biermann, Katharina
AU - Tjwa, Eric T T L
PY - 2014
Y1 - 2014
N2 - Chronic gastrointestinal ischemia (CGI) is the result of decreased mucosal perfusion. Typical histological characteristics are lacking which hamper its early diagnosis. Hypoxia-inducible factor-1α (HIF-1α) is expressed under acute hypoxia. We investigated HIF-1α expression in chronic ischemic and inflammatory conditions of the human gastrointestinal (GI) tract. Immunohistochemical expression of HIF-1α was analyzed in 61 patients, including patients with CGI, Helicobacter pylori gastritis, ischemic colitis (IC), infectious colitis, and inflammatory bowel disease (IBD), and 22 controls. HIF-1α expression in >10 % of the cells was regarded as positive staining, and expression
AB - Chronic gastrointestinal ischemia (CGI) is the result of decreased mucosal perfusion. Typical histological characteristics are lacking which hamper its early diagnosis. Hypoxia-inducible factor-1α (HIF-1α) is expressed under acute hypoxia. We investigated HIF-1α expression in chronic ischemic and inflammatory conditions of the human gastrointestinal (GI) tract. Immunohistochemical expression of HIF-1α was analyzed in 61 patients, including patients with CGI, Helicobacter pylori gastritis, ischemic colitis (IC), infectious colitis, and inflammatory bowel disease (IBD), and 22 controls. HIF-1α expression in >10 % of the cells was regarded as positive staining, and expression
KW - Chronic gastrointestinal ischemia
KW - Hypoxia
KW - Hypoxia-inducible factor-1α
KW - Immunohistochemistry
KW - Inflammation
KW - Ischemic colitis
UR - http://www.scopus.com/inward/record.url?scp=84925486984&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84925486984&partnerID=8YFLogxK
U2 - 10.1007/s00428-014-1691-6
DO - 10.1007/s00428-014-1691-6
M3 - Article
VL - 466
SP - 125
EP - 132
JO - Virchows Archiv
JF - Virchows Archiv
SN - 0945-6317
IS - 2
ER -