TY - JOUR
T1 - Hypoxia in tumors
T2 - A paradigm for the approach to biochemical and physiologic heterogeneity
AU - Coleman, C. Norman
PY - 1988/5/4
Y1 - 1988/5/4
N2 - While the inherent radiosensitivity of tumor cells is likely to affect treatment outcome, the biochemical and physiologic state of the cell may have a major impact. Tumors are likely to be highly heterogeneous for these dynamic properties. Hypoxic cells are radioresistant, requiring two to three times the radiation dose to kill them compared to the same cells in a eu-oxic state. Hypoxia can be of two types: 1) chronic hypoxia, which is diffusion limited, and 2) acute hypoxia, which is perfusion limited. The mechanism of and approaches toward these are different and can serve as a model for other biochemical and physiologic processes that may affect treatment outcome.
AB - While the inherent radiosensitivity of tumor cells is likely to affect treatment outcome, the biochemical and physiologic state of the cell may have a major impact. Tumors are likely to be highly heterogeneous for these dynamic properties. Hypoxic cells are radioresistant, requiring two to three times the radiation dose to kill them compared to the same cells in a eu-oxic state. Hypoxia can be of two types: 1) chronic hypoxia, which is diffusion limited, and 2) acute hypoxia, which is perfusion limited. The mechanism of and approaches toward these are different and can serve as a model for other biochemical and physiologic processes that may affect treatment outcome.
UR - http://www.scopus.com/inward/record.url?scp=0023910405&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023910405&partnerID=8YFLogxK
U2 - 10.1093/jnci/80.5.310
DO - 10.1093/jnci/80.5.310
M3 - Review article
C2 - 3282077
AN - SCOPUS:0023910405
SN - 0027-8874
VL - 80
SP - 310
EP - 317
JO - Journal of the National Cancer Institute
JF - Journal of the National Cancer Institute
IS - 5
ER -