Hypoxia and the extracellular matrix: Drivers of tumour metastasis

Research output: Contribution to journalArticle

Abstract

Of the deaths attributed to cancer, 90% are due to metastasis, and treatments that prevent or cure metastasis remain elusive. Emerging data indicate that hypoxia and the extracellular matrix (ECM) might have crucial roles in metastasis. During tumour evolution, changes in the composition and the overall content of the ECM reflect both its biophysical and biological properties and these strongly influence tumour and stromal cell properties, such as proliferation and motility. Originally thought of as independent contributors to metastatic spread, recent studies have established a direct link between hypoxia and the composition and the organization of the ECM, which suggests a new model in which multiple microenvironmental signals might converge to synergistically influence metastatic outcome.

Original languageEnglish (US)
Pages (from-to)430-439
Number of pages10
JournalNature Reviews Cancer
Volume14
Issue number6
DOIs
StatePublished - 2014

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Extracellular Matrix
Neoplasm Metastasis
Neoplasms
Stromal Cells
Hypoxia

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Hypoxia and the extracellular matrix : Drivers of tumour metastasis. / Gilkes, Daniele; Semenza, Gregg L; Wirtz, Denis.

In: Nature Reviews Cancer, Vol. 14, No. 6, 2014, p. 430-439.

Research output: Contribution to journalArticle

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